Migration Assay: Cells expressing recombinant CCR2 were assayed for migration through a transwell filter at various concentrations of MCP-3. Responses are expressed as the % of total input cells.

Monocyte chemotactic protein 3 (MCP-3/CCL7) 6007

$61.00 – $2,189.00

Summary

Expression: E.coli
Amino Acid Range: 24-99

SKU: 6007parent Categories: chemokine, proteins Tag: CCL7 (MCP-3)

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P80098
express system	E.coli
product tag	none
purity	> 97% by SDS PAGE
molecular weight	Predicted Molecular Mass: 8.956 kDa Extinction Coefficient: 8,730 M-1 cm-1 Actual Molecular Mass: 8.956 kDa by ESI Mass Spec
available size	10 µg, 100 µg, 1mg, 2 µg, 50 µg
endotoxin	<0.01 EU per 1μg of the protein by the LAL method
sequence	QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWV QDFMKHLDKKTQTPKL

Monocyte chemotactic protein 3 (MCP-3/CCL7) 6007

protein
Database link: human P80098
Size and concentration 5, 20, 50, 100, 1000µg and lyophilized
Form Lyophilized
Storage Instructions Avoid repeated freeze-thaw cycles: • 12 months from date of receipt, -20 to -70 °C as supplied. • 1 month, 2 to 8 °C under sterile conditions after reconstitution. • 3 months, -20 to -70 °C under sterile conditions after reconstitution
Storage buffer Reconstitution: Spin sample prior to reconstitution. Recommended concentration of 100µg/mL in sterile water. Shipping: Room Temp
Purity > 97% by SDS PAGE and HPLC

target relevance
Monocyte protein 3 (MCP-3/CCL7) is secreted by monocytes and certain tumor cell lines. It is a chemoattractant for monocytes and other leukocytes. MCP-3 binds and signals through several chemokine receptors including CCR1, CCR2, CCR3, and appears to be an antagonist for CCR5.
Protein names C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
Gene names CCL7,CCL7 MCP3 SCYA6 SCYA7
Protein family Intercrine beta (chemokine CC) family
Mass 11200Da
Function Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
Subellular location Secreted.
Structure Monomer. Interacts with TNFAIP6 (via Link domain).
Post-translational modification O-glycosylated.
Target Relevance information above includes information from UniProt accession: P80098
The UniProt Consortium

Data

Migration Assay: Cells expressing recombinant CCR2 were assayed for migration through a transwell filter at various concentrations of MCP-3. Responses are expressed as the % of total input cells.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.