Oxidative stress

We are excited to offer a novel, high-value antibody, the mouse monoclonal antibody (6E4), which targets 8-oxoA, a C8-oxidized adenine lesion arising in DNA, RNA, and free nucleosides. 6E4 exhibits exquisite selectivity for 8-oxoA over a chemically diverse mixture of native, methylated, and oxidized nucleoside antigens, including 8-oxoG, 2-oxoA, m6A, and 5-hoU. It specifically senses 8-oxoA in nucleoside triphosphates (8-oxoATP) and DNA/RNA oligonucleotides containing a single 8-oxoA. Importantly, 6E4 discerns 8-oxoA in double-stranded DNA/RNA antigens, whether paired correctly or base mismatched. This antibody is well-suited for a broad range of immunodetection applications in nucleic acid quality control and sequencing. For enzymatic antioxidant markers, we offer antibodies that target crucial enzymes like superoxide dismutase, catalase, and glutathione peroxidase, which play pivotal roles in neutralizing reactive oxygen species. Inflammatory markers linked to oxidative stress are well-represented with antibodies against cytokines and chemokines that mediate the inflammatory response. Our selection also encompasses non-enzymatic antioxidant markers, such as those targeting vitamins and thiols that contribute to the cellular antioxidant defense. We provide antibodies for oxidative damage markers, including those that detect protein carbonyls and lipid peroxidation products, indicating cellular damage. Redox signaling markers are crucial for understanding cellular redox balance, and our antibodies against key signaling molecules help elucidate these pathways. Additionally, we offer mitochondrial markers that highlight the role of mitochondria in oxidative stress and cellular metabolism. Our catalog includes antibodies for additional cellular markers involved in oxidative stress responses and signal transduction pathways, providing insights into cellular communication and regulatory mechanisms. Furthermore, we offer small molecules of oxidative stress to study their roles in various biological processes.