Oxidized LDL (oxLDL), protein 1011

Price range: $476.00 through $764.00

Antibody summary

Rabbit polyclonal to Oxidized LDL (oxLDL)
Suitable for: WB,IP
Reacts with: Oxidized LDL
Isotype:
0.5 mg, 1mg

SKU: 1011parent Categories: antibody, oxidative stress Tag: ox LDL

Weight	1 lbs
Dimensions	9 × 5 × 2 in
concentration	1 mg/mL
applications	IP, WB
reactivity	Oxidized LDL (oxLDL), protein
available sizes	0.5 mg, 1 mg

oxidized LDL antigen 1011

antibody

Tested applications WB,IP
Size and concentration 500µg and 1 mg/mL
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Storage buffer 10 mM PBS, 140 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.0

target relevance

OX-LDL

Protein names
Low-density lipoprotein (LDL)

Alternative names
LDL, Beta-lipoprotein

Function
LDL serves as the primary carrier of cholesterol in human plasma and delivers cholesterol to cells through receptor-mediated uptake via the LDL receptor.

Subcellular location
Extracellular; circulating plasma lipoprotein particle.

Involvement in disease
Elevated LDL levels are a major risk factor for atherosclerosis and cardiovascular disease. Oxidized, nitrated, and MDA-modified LDL particles are implicated in plaque formation, endothelial dysfunction, inflammation, and foam cell development.

Description
Low-density lipoprotein (LDL) is a plasma lipoprotein particle responsible for transporting cholesterol and other lipids from the liver to peripheral tissues.

Biological role
Cholesterol transport
Lipid metabolism
Lipoprotein metabolism
Atherosclerosis-associated particle

Pathways
Lipoprotein metabolism
Cholesterol homeostasis
LDL receptor pathway

Research relevance
Native LDL, oxidized LDL (oxLDL), MDA-LDL, and nitrated LDL are widely used biomarkers in cardiovascular, inflammatory, oxidative stress, and metabolic disease research.

Modified forms
name: Oxidized LDL; abbreviation: oxLDL; description: LDL modified by reactive oxygen species resulting in lipid peroxidation and oxidative modification of ApoB.
name: Malondialdehyde-modified LDL; abbreviation: MDA-LDL; description: LDL containing malondialdehyde adducts generated during lipid peroxidation.
name: Nitrated LDL; abbreviation: NO2-LDL; description: LDL modified by reactive nitrogen species causing nitration of lipids and ApoB residues.

Keywords
Lipoprotein, Cholesterol transport, Atherosclerosis, Oxidized LDL, MDA-LDL, Nitrated LDL

Structure
LDL is a lipid-protein particle containing a single APOB molecule surrounding a core of cholesteryl esters and triglycerides.

Function
LDL transports cholesterol from the liver to peripheral tissues through LDL receptor-mediated uptake.

Oxidized LDL
Oxidative modification of LDL generates oxLDL, which promotes macrophage uptake, foam cell formation, endothelial dysfunction, and vascular inflammation.

MDA-LDL
MDA-LDL contains malondialdehyde adducts formed during lipid peroxidation and is a commonly measured marker of oxidative stress and atherosclerosis.

Nitrated LDL
Nitrated LDL results from reactive nitrogen species-mediated modification of LDL and has been implicated in vascular injury and inflammatory responses.

Research relevance
Native LDL and its modified forms are extensively studied biomarkers in cardiovascular disease, inflammation, oxidative stress, diabetes, and metabolic syndrome.

Low density lipoprotein (LDL)

NITR-LDL