Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | rabbit |
isotype | IgG |
clonality | polyclonal |
concentration | 1 mg/mL |
applications | IP, WB |
reactivity | polyclonal, rabbit, TRX1 |
available sizes | 10 µL, 100 µL |
rabbit anti-thioredoxin (TRX1) polyclonal antibody 1004
$121.00 – $2,600.00
Antibody summary
- Rabbit polyclonal to Thioredoxin (Trx1)
- Suitable for: IP,WB
- Reacts with: Hu
- Isotype: IgG
- 100 µL, 10 µL
rabbit anti-TRX1 polyclonal antibody 1004
target relevance |
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Protein names Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx) |
Gene names TXN,TXN TRDX TRX TRX1 |
Protein family Thioredoxin family |
Mass 11737Da |
Function Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:11118054, PubMed:9108029).; ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). |
Subellular location Nucleus. Cytoplasm. Secreted. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). |
Structure Homodimer; disulfide-linked (PubMed:17260951, PubMed:9369469). Interacts with TXNIP through the redox-active site (PubMed:17260951). Interacts with MAP3K5 and CASP3 (PubMed:15246877). In case of infection, interacts with S.typhimurium protein slrP (PubMed:19690162). Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (PubMed:9108029). |
Post-translational modification In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.; In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation. |
Target Relevance information above includes information from UniProt accession: P10599 |
The UniProt Consortium |
Publications
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