Immunohistochemistry (IHC) : Human tonsil stained with anti-CD38 antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of perifollicular and subepithelial plasma cells.

rabbit anti-CD38 monoclonal antibody (ZR351) 6090

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to CD38
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Tonsil
Visualization: Cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

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SKU: 6090parent Category: antibody Tags: anatomy, CD38, Hematopathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-CD38 monoclonal antibody ZR351 6090

antibody
Database link: human P28907
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Application Notes Positive control: Tonsil
Immunogen Peptide derived from the C-terminus of human CD38 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)
Gene names CD38,CD38
Protein family ADP-ribosyl cyclase family
Mass 34328Da
Function FUNCTION: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715). {ECO:0000269\|PubMed:16690024, ECO:0000269\|PubMed:7961800, ECO:0000269\|PubMed:8253715}.
Catalytic activity CATALYTIC ACTIVITY: Reaction=2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate; Xref=Rhea:RHEA:38607, ChEBI:CHEBI:32544, ChEBI:CHEBI:75967, ChEBI:CHEBI:75970; Evidence={ECO:0000269\|PubMed:16690024}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38608; Evidence={ECO:0000269\|PubMed:16690024}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38609; Evidence={ECO:0000269\|PubMed:16690024}; CATALYTIC ACTIVITY: Reaction=NAD(+) = cyclic ADP-beta-D-ribose + nicotinamide + H(+); Xref=Rhea:RHEA:38611, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:73672; Evidence={ECO:0000269\|PubMed:7961800, ECO:0000269\|PubMed:8253715}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38612; Evidence={ECO:0000269\|PubMed:8253715}; CATALYTIC ACTIVITY: Reaction=NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+); Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000269\|PubMed:16690024, ECO:0000269\|PubMed:8253715}; CATALYTIC ACTIVITY: Reaction=cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose; Xref=Rhea:RHEA:38615, ChEBI:CHEBI:15377, ChEBI:CHEBI:57967, ChEBI:CHEBI:73672; Evidence={ECO:0000269\|PubMed:7961800, ECO:0000269\|PubMed:8253715}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38616; Evidence={ECO:0000269\|PubMed:8253715}; CATALYTIC ACTIVITY: Reaction=NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide; Xref=Rhea:RHEA:38603, ChEBI:CHEBI:17154, ChEBI:CHEBI:58349, ChEBI:CHEBI:75970; Evidence={ECO:0000269\|PubMed:16690024}; CATALYTIC ACTIVITY: Reaction=nicotinate + NADP(+) = nicotinate-adenine dinucleotide phosphate + nicotinamide; Xref=Rhea:RHEA:38599, ChEBI:CHEBI:17154, ChEBI:CHEBI:32544, ChEBI:CHEBI:58349, ChEBI:CHEBI:75967; EC=2.4.99.20; Evidence={ECO:0000305\|PubMed:16690024}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38600; Evidence={ECO:0000305\|PubMed:16690024};
Subellular location SUBCELLULAR LOCATION: Cell surface {ECO:0000269\|PubMed:2319135}. Membrane {ECO:0000269\|PubMed:8253715}; Single-pass type II membrane protein.
Tissues TISSUE SPECIFICITY: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269\|PubMed:8253715, ECO:0000269\|PubMed:9074508}.
Structure SUBUNIT: Homodimer. {ECO:0000305\|PubMed:16154090}.
Target Relevance information above includes information from UniProt accession: P28907
The UniProt Consortium

Data

Human tonsil stained with anti-CD38 antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of perifollicular and subepithelial plasma cells.

Publications

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Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.