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mouse anti-Tryptase monoclonal antibody (ZM96) 6439

$160.00$528.00

Antibody summary

  • Mouse monoclonal to Tryptase
  • Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
  • Reacts with: Human
  • Isotype:IgG1
  • Control: Mast cells containing tissue or tumors
  • Visualization: Cytoplasmic
  • 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
SKU: 6439parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

mouse

isotype

IgG1

clonality

monoclonal

concentration

concentrate, predilute

applications

IHC

reactivity

human

available size

0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

mouse anti-Tryptase monoclonal antibody ZM96 6439

antibody
Database link:
human P20231
Tested applications
IHC
Recommended dilutions
As directed
Immunogen
Synthesized peptide corresponding to the C-terminus of human TRPS1 protein
Size and concentration
7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form
liquid
Storage Instructions
2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity
affinity purified
Clonality
monoclonal
Isotype
IgG1
Compatible secondaries
goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486
goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685
goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854
goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706
goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716
goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control
Mouse monoclonal IgG1 - Isotype Control
target relevance
Protein names
Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II)
Protein family
Peptidase S1 family, Tryptase subfamily
Mass
30651Da
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. .
Catalytic activity
CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.; EC=3.4.21.59;
Subellular location
Secreted. Note=Released from the secretory granules upon mast cell activation.
Structure
Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6. .
Domain
DOMAIN 31..272; /note="Peptidase S1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
Target Relevance information above includes information from UniProt accession: P20231
The UniProt Consortium

Data

Human tonsil stained with anti-tryptase antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of scattered mast cells.
Human tonsil stained with anti-tryptase antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of scattered mast cells.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product
IHC

Documents

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