Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | mouse |
isotype | IgG1 |
clonality | monoclonal |
concentration | concentrate, predilute |
applications | IHC |
reactivity | human |
available size | 0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted |
mouse anti-Tryptase monoclonal antibody (ZM96) 6439
$160.00 – $528.00
Antibody summary
- Mouse monoclonal to Tryptase
- Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
- Reacts with: Human
- Isotype:IgG1
- Control: Mast cells containing tissue or tumors
- Visualization: Cytoplasmic
- 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
mouse anti-Tryptase monoclonal antibody ZM96 6439
target relevance |
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Protein names Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II) |
Protein family Peptidase S1 family, Tryptase subfamily |
Mass 30651Da |
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. . |
Catalytic activity CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.; EC=3.4.21.59; |
Subellular location Secreted. Note=Released from the secretory granules upon mast cell activation. |
Structure Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6. . |
Domain DOMAIN 31..272; /note="Peptidase S1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00274" |
Target Relevance information above includes information from UniProt accession: P20231 |
The UniProt Consortium |
Data
Human tonsil stained with anti-tryptase antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of scattered mast cells. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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IHC |
Documents
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