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rabbit anti-OCT-2 monoclonal antibody (ZR227) 6297

$160.00$528.00

Antibody summary

  • Rabbit monoclonal to OCT-2
  • Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
  • Reacts with: Human
  • Isotype:IgG
  • Control: B-cell lymphoma
  • Visualization: Nuclear
  • 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
SKU: 6297parent Category: Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

mouse

isotype

IgG

clonality

monoclonal

concentration

concentrate, predilute

applications

IHC

reactivity

human

available size

0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-OCT-2 monoclonal antibody ZR227 6297

antibody
Database link:
human P09086
Tested applications
IHC
Recommended dilutions
As directed
Immunogen
A peptide corresponding to human NUT protein
Size and concentration
7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form
liquid
Storage Instructions
2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity
affinity purified
Clonality
monoclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
Protein names
POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)
Protein family
POU transcription factor family, Class-2 subfamily
Mass
51209Da
Function
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). .; [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. .
Subellular location
Cytoplasm . Nucleus.
Tissues
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. .
Structure
Interacts with NR3C1, AR and PGR (PubMed:10480874). Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity (PubMed:7859290). .
Domain
DOMAIN 195..269; /note="POU-specific"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
Target Relevance information above includes information from UniProt accession: P09086
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human lymph node stained with anti-OCT2 antibody using peroxidase-conjugate and DAB chromogen.  Note nuclear staining of follicular B cells
Formalin-fixed, paraffin-embedded human lymph node stained with anti-OCT2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of follicular B cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product
IHC

Documents

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