Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human tonsil stained with anti-CD138 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of plasma cells and squamous epithelium

rabbit anti-CD138 monoclonal antibody (ZR251) 6061

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to CD138
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Tonsil
Visualization: Cell membrane/cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6061parent Category: antibody Tags: anatomy, CD138, Hematopathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-CD138 monoclonal antibody ZR251 6061

antibody
Database link: human P18827
Tested applications IHC
Recommended dilutions As directed
Immunogen Recombinant fragment (around aa50-250) of human ANPEP protein (exact sequence is proprietary)
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Syndecan-1 (SYND1) (CD antigen CD138)
Protein family Syndecan proteoglycan family
Mass 32462Da
Function Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250\|UniProtKB:P18828, ECO:0000269\|PubMed:22660413}.
Subellular location Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269\|PubMed:9169435}. Secreted, extracellular exosome {ECO:0000269\|PubMed:22660413}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269\|PubMed:9169435}.
Tissues Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313). {ECO:0000269\|PubMed:32337544, ECO:0000269\|PubMed:36213313}.
Structure Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity). {ECO:0000250\|UniProtKB:P26260, ECO:0000269\|PubMed:16007225, ECO:0000269\|PubMed:23395182}.
Post-translational modification Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. {ECO:0000269\|PubMed:9169435}.
Target Relevance information above includes information from UniProt accession: P18827
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human tonsil stained with anti-CD138 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of plasma cells and squamous epithelium

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.