Leptospira biflexa Antigen BA125VS

$943.00

Summary

Virion/Serion Immunologics Antigen for research use (RUO)
Leptospira biflexa Antigen, recombinant
Suitable for detection of IgA, IgG & IgM antibodies in ELISA
Lot specific concentration, specified in mg/mL
1 mg

SKU: BA125VS Category: Infectious disease proteins Tags: antigen, Leptospira, protein

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Leptospira biflexa
species reactivity	Leptospira
applications	ELISA
assay type	Indirect & quantitative
available size	1 mg

Leptospira biflexa Antigen BA125VS

kit
Research area Infectious Disease
Storage Store at -65°C or lower. Avoid repeated freeze-thaw cycles. Sonicate before use. 10 years from date of manufacture (under recommended storage conditions).
Form liquid
Associated products Leptospira biflexa Antigen (BA125VS) Leptospira IgG Control Serum (BC125G) Leptospira IgM Control Serum (BC125M) Leptospira IgG ELISA Kit (ESR125G) Leptospira IgM ELISA Kit (ESR125M)

target relevance
Leptospira
Description Spirochete bacterium that causes leptospirosis
Structure Leptospira is a genus of thin, highly motile, Gram-negative spirochete bacteria belonging to the family Leptospiraceae. Members of the genus possess a characteristic tightly coiled helical morphology with hooked ends, often described as question mark-shaped. The bacteria are widely distributed in nature and are maintained in the kidneys of a broad range of wild and domestic animals, including rodents, cattle, pigs, dogs, and wildlife species. Pathogenic Leptospira species are shed into the environment through urine and can survive for extended periods in moist soil and freshwater. Human infection occurs through direct contact with infected animals or exposure to water, soil, or food contaminated with infected urine. Leptospira organisms are capable of penetrating mucous membranes and damaged skin, disseminating through the bloodstream, and infecting multiple organ systems.
Diagnosis The diagnosis of leptospirosis is performed through serological, molecular, microbiological, and microscopic methods. The microscopic agglutination test (MAT) is considered the reference serological method and is widely used to detect antibodies against Leptospira. ELISA-based assays are commonly employed for screening and diagnosis due to their simplicity and sensitivity. Molecular methods such as polymerase chain reaction (PCR) provide rapid detection of Leptospira DNA during the early phase of infection before antibodies become detectable. Culture of Leptospira from blood, cerebrospinal fluid, or urine is possible but technically demanding and may require prolonged incubation. Laboratory findings often include elevated liver enzymes, renal dysfunction, thrombocytopenia, and inflammatory markers. Early diagnosis is essential because prompt antimicrobial therapy can reduce disease severity and complications.
Symptoms Leptospirosis typically develops following an incubation period of approximately two to thirty days, most commonly seven to twelve days after exposure. The disease often begins abruptly with fever, chills, severe headache, muscle aches, particularly involving the calves and lower back, fatigue, nausea, vomiting, and conjunctival suffusion. Many infections are mild and self-limiting; however, severe disease may develop and is known as Weil's disease. This severe form is characterized by jaundice, acute kidney injury, liver dysfunction, hemorrhage, meningitis, myocarditis, respiratory distress, and multi-organ failure. Pulmonary involvement can result in life-threatening pulmonary hemorrhage syndrome. Without prompt treatment, severe leptospirosis can be fatal, particularly in elderly individuals and patients with significant organ involvement.

Data

FAQ & Publications

Frequently Asked Questions

What is the recommended storage condition for the Leptospira biflexa Antigen BA125VS?

The antigen should be stored at -65°C or lower, avoiding repeated freeze-thaw cycles, to maintain stability for up to 10 years from the date of manufacture under these conditions.

For what types of antibodies is the Leptospira biflexa Antigen BA125VS suitable in ELISA assays?

This recombinant antigen is suitable for the detection of IgA, IgG, and IgM antibodies in ELISA applications.

Which Leptospira species does the Leptospira biflexa Antigen BA125VS target?

The antigen targets Leptospira biflexa and is reactive with Leptospira species.

What assay formats is the Leptospira biflexa Antigen BA125VS validated for?

It is validated for use in indirect and quantitative ELISA assays.

What is the form and available size of the Leptospira biflexa Antigen BA125VS?

The product is supplied as a liquid recombinant antigen in a 1 mg size.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.