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Leptospira IgG ELISA kit-SERION <i>classic</i> ESR125G - Image 2

Leptospira IgG ELISA kit-SERION classic ESR125G

$355.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Leptospira IgG ELISA Kit
Suitable for IgG detection
Ready-to-use
96 tests

SKU: ESR125G Category: Virion/Serion kits Tags: ELISA, IgG, Leptospira

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Leptospira reactive IgG
species reactivity	Leptospira
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Leptospira IgG ELISA Kit ESR125G

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgG-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

Associated products
Leptospira biflexa Antigen (BA125VS)
Leptospira IgG Control Serum (BC125G)
Leptospira IgM Control Serum (BC125M)
Leptospira IgG ELISA Kit (ESR125G)
Leptospira IgM ELISA Kit (ESR125M)

target relevance

human antibody anti-Leptospira

Leptospira

Description
Spirochete bacterium that causes leptospirosis

Structure
Leptospira is a genus of thin, highly motile, Gram-negative spirochete bacteria belonging to the family Leptospiraceae. Members of the genus possess a characteristic tightly coiled helical morphology with hooked ends, often described as question mark-shaped. The bacteria are widely distributed in nature and are maintained in the kidneys of a broad range of wild and domestic animals, including rodents, cattle, pigs, dogs, and wildlife species. Pathogenic Leptospira species are shed into the environment through urine and can survive for extended periods in moist soil and freshwater. Human infection occurs through direct contact with infected animals or exposure to water, soil, or food contaminated with infected urine. Leptospira organisms are capable of penetrating mucous membranes and damaged skin, disseminating through the bloodstream, and infecting multiple organ systems.

Diagnosis
The diagnosis of leptospirosis is performed through serological, molecular, microbiological, and microscopic methods. The microscopic agglutination test (MAT) is considered the reference serological method and is widely used to detect antibodies against Leptospira. ELISA-based assays are commonly employed for screening and diagnosis due to their simplicity and sensitivity. Molecular methods such as polymerase chain reaction (PCR) provide rapid detection of Leptospira DNA during the early phase of infection before antibodies become detectable. Culture of Leptospira from blood, cerebrospinal fluid, or urine is possible but technically demanding and may require prolonged incubation. Laboratory findings often include elevated liver enzymes, renal dysfunction, thrombocytopenia, and inflammatory markers. Early diagnosis is essential because prompt antimicrobial therapy can reduce disease severity and complications.

Symptoms
Leptospirosis typically develops following an incubation period of approximately two to thirty days, most commonly seven to twelve days after exposure. The disease often begins abruptly with fever, chills, severe headache, muscle aches, particularly involving the calves and lower back, fatigue, nausea, vomiting, and conjunctival suffusion. Many infections are mild and self-limiting; however, severe disease may develop and is known as Weil's disease. This severe form is characterized by jaundice, acute kidney injury, liver dysfunction, hemorrhage, meningitis, myocarditis, respiratory distress, and multi-organ failure. Pulmonary involvement can result in life-threatening pulmonary hemorrhage syndrome. Without prompt treatment, severe leptospirosis can be fatal, particularly in elderly individuals and patients with significant organ involvement.

Data

FAQ & Publications

Frequently Asked Questions

What type of antibody does the Leptospira IgG ELISA Kit ESR125G detect?

The kit is designed to detect IgG antibodies reactive to Leptospira species.

Which sample types are compatible with this ELISA kit for detecting Leptospira IgG?

The assay is compatible with serum, plasma, and whole blood samples.

How should the Leptospira IgG ELISA Kit ESR125G be stored to maintain stability?

The kit should be stored at 2-8°C to preserve reagent integrity and functionality.

What is the format and assay type of the Leptospira IgG ELISA Kit ESR125G?

This product uses an indirect and quantitative ELISA assay format with break apart microtiter test strips.

Does the kit include quality control materials and standards for assay validation?

Yes, the kit contains a quality control certificate with a standard curve and evaluation table, along with standard and negative control sera.

Publications

pmid	title	authors	citation
38243162	A rare case of anti-DPPX encephalitis combined with neuroleptospirosis.	Yong Jin, Wei Lan, Xiaodong Chen, Wu Liu, Weiliang Luo, Suqin Chen	BMC Neurol 24:34
37524788	Seroprevalence of leptospirosis among blood donors in an endemic area.	Umaporn Limothai, Sasipha Tachaboon, Janejira Dinhuzen, Jasleen Singh, Sirawit Jirawannaporn, Akarathep Leewongworasingh, Matsaya Thongpin, Suppalak Brameld, Phandee Watanaboonyongcharoen, Visith Sitprija, Terapong Tantawichien, Usa Thisyakorn, Nattachai Srisawat	Sci Rep 13:12336
36136619	Serological Investigation and Epidemiological Analysis of Bovine Leptospirosis in Egypt.	Nermin Awade Ibrahim, Barakat M Alrashdi, Yasser Fathi Elnaker, Ehab Kotb Elmahallawy, Mohamed A Alblihed, Mohamed Said Daib, Amany M Abd Elmoety, Eman A Abo Elfadl, Basma M Badawy, Elzahara Elbaz	Trop Med Infect Dis 7:N/A
34611273	Evaluation of a genus-specific rGroEL(1-524) IgM-ELISA and commercial ELISA kits during the course of leptospirosis in Thailand.	Santi Maneewatchararangsri, Galayanee Doungchawee, Thareerat Kalambaheti, Viravarn Luvira, Ngamphol Soonthornworasiri, Pisut Vattanatham, Urai Chaisri, Poom Adisakwattana	Sci Rep 11:19785
32103771	Leptospirosis in Indonesia: diagnostic challenges associated with atypical clinical manifestations and limited laboratory capacity.	Muhammad Hussein Gasem, Usman Hadi, Bachti Alisjahbana, Emiliana Tjitra, M M D E A H Hapsari, Endang Sri Lestari, Abu Tholib Aman, Dewi Lokida, Gustiani Salim, Herman Kosasih, Ketut Tuti Parwati Merati, Kanti Laras, Mansyur Arif, Nurhayati Lukman, Pratiwi Sudarmono, Vivi Lisdawati, Chuen-Yen Lau, Aaron Neal, Muhammad Karyana	BMC Infect Dis 20:179

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR125G protocol

Documents

#
EP0051	Safety Data Sheet	QC certificate
EQ0066	Safety Data Sheet	QC certificate
ER0041	Safety Data Sheet	QC certificate

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Leptospira IgG ELISA kit-SERION classic ESR125G

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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