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Legionella pneumophila 1-7 IgM ELISA kit-SERION classic ESR106M

$364.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Legionella pneumophila 1-7 IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR106M Category: Virion/Serion kits Tags: ELISA, IgM, Legionella pneumophila

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Legionella pneumophila 1-7 reactive IgM
species reactivity	Legionella pneumophila
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Legionella pneumophila 1-7 IgM ELISA Kit ESR106M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

Associated products
Legionella pneumophila Antigen (BA106VS)
Legionella pneumophila IgG Control Serum (BC106G)
Legionella pneumophila IgM Control Serum (BC106M)
Legionella pneumophila 1-7 IgG ELISA Kit (ESR106G)
Legionella pneumophila 1-7 IgM ELISA Kit (ESR106M)

target relevance

human antibody anti-Legionella pneumophila

Legionella pneumophila

Description
Bacterium that causes Legionnaires' disease and Pontiac fever

Structure
Legionella pneumophila is a Gram-negative, aerobic, rod-shaped bacterium belonging to the family Legionellaceae. The organism is naturally found in freshwater environments, including lakes, rivers, and streams, where it survives and replicates within free-living amoebae and other protozoa. In man-made water systems such as cooling towers, hot water tanks, plumbing systems, decorative fountains, and whirlpool spas, Legionella can proliferate under favorable conditions and form biofilms that enhance survival and persistence. L. pneumophila is a facultative intracellular pathogen that infects and replicates within alveolar macrophages and other host cells by preventing phagosome-lysosome fusion. Serogroup 1 is responsible for the majority of human infections. Legionella pneumophila is the primary causative agent of Legionnaires' disease, a severe form of pneumonia, and Pontiac fever, a milder self-limiting illness.

Diagnosis
The diagnosis of Legionella pneumophila infection is performed through microbiological, molecular, and antigen detection methods. Detection of Legionella urinary antigen, particularly for L. pneumophila serogroup 1, is widely used due to its rapidity and high specificity. Polymerase chain reaction (PCR) assays performed on respiratory specimens provide highly sensitive detection and may identify a broader range of Legionella species and serogroups. Culture of respiratory samples on specialized buffered charcoal yeast extract (BCYE) agar remains the definitive diagnostic method and allows epidemiological comparison of clinical and environmental isolates. Serological testing may be used for retrospective diagnosis but is less useful for acute clinical management. Early diagnosis is important because prompt antimicrobial therapy significantly improves outcomes.

Symptoms
Legionella pneumophila infection most commonly occurs following inhalation of contaminated aerosols generated from water systems. After an incubation period of approximately two to ten days, Legionnaires' disease typically presents with high fever, chills, cough, shortness of breath, fatigue, headache, muscle aches, and malaise. Gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain are common and may help distinguish Legionnaires' disease from other causes of pneumonia. Neurological manifestations including confusion, disorientation, and altered mental status may also occur. Severe infections can progress to respiratory failure, septic shock, multi-organ dysfunction, and death, particularly in elderly individuals, smokers, immunocompromised patients, and those with chronic underlying diseases. Pontiac fever presents as a milder influenza-like illness without pneumonia and generally resolves spontaneously within several days.

Data

FAQ & Publications

Frequently Asked Questions

What types of samples are compatible with the Legionella pneumophila 1-7 IgM ELISA Kit ESR106M?

The kit is suitable for testing serum, plasma, and whole blood samples for the detection of Legionella pneumophila 1-7 reactive IgM antibodies.

How should the Legionella pneumophila 1-7 IgM ELISA Kit ESR106M be stored to maintain its stability?

The kit components should be stored at 2-8°C to ensure optimal stability and performance.

Is there a recommended pretreatment step to improve specificity when using this IgM ELISA kit?

Yes, it is recommended to pretreat samples with RF-Absorbent Z200 to remove IgM rheumatoid factors, which helps eliminate possible false negative results and improves signal specificity.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR106M protocol

Documents

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Legionella pneumophila 1-7 IgM ELISA kit-SERION classic ESR106M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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