Legionella pneumophila IgM Control Serum BC106M

$94.00

Summary

Virion/Serion Diagnostic Kit Control for research use (RUO)
Legionella pneumophila IgM Control Serum
Applications: ELISA
IgM control serum
Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
3 mL

SKU: BC106M Categories: control serum, Virion/Serion kits Tags: ELISA control serum, IgM, Legionella pneumophila

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Legionella pneumophila reactive IgM
species reactivity	Legionella pneumophila
applications	ELISA
assay type	Indirect & quantitative
available size	3 mL

Legionella pneumophila IgM Control Serum BC106M

kit
Research area Infectious Disease
Storage Store at 2-8°C.
Associated products Legionella pneumophila Antigen (BA106VS) Legionella pneumophila IgG Control Serum (BC106G) Legionella pneumophila IgM Control Serum (BC106M) Legionella pneumophila 1-7 IgG ELISA Kit (ESR106G) Legionella pneumophila 1-7 IgM ELISA Kit (ESR106M)

target relevance

human antibody anti-Legionella pneumophila

Legionella pneumophila

Description
Bacterium that causes Legionnaires' disease and Pontiac fever

Structure
Legionella pneumophila is a Gram-negative, aerobic, rod-shaped bacterium belonging to the family Legionellaceae. The organism is naturally found in freshwater environments, including lakes, rivers, and streams, where it survives and replicates within free-living amoebae and other protozoa. In man-made water systems such as cooling towers, hot water tanks, plumbing systems, decorative fountains, and whirlpool spas, Legionella can proliferate under favorable conditions and form biofilms that enhance survival and persistence. L. pneumophila is a facultative intracellular pathogen that infects and replicates within alveolar macrophages and other host cells by preventing phagosome-lysosome fusion. Serogroup 1 is responsible for the majority of human infections. Legionella pneumophila is the primary causative agent of Legionnaires' disease, a severe form of pneumonia, and Pontiac fever, a milder self-limiting illness.

Diagnosis
The diagnosis of Legionella pneumophila infection is performed through microbiological, molecular, and antigen detection methods. Detection of Legionella urinary antigen, particularly for L. pneumophila serogroup 1, is widely used due to its rapidity and high specificity. Polymerase chain reaction (PCR) assays performed on respiratory specimens provide highly sensitive detection and may identify a broader range of Legionella species and serogroups. Culture of respiratory samples on specialized buffered charcoal yeast extract (BCYE) agar remains the definitive diagnostic method and allows epidemiological comparison of clinical and environmental isolates. Serological testing may be used for retrospective diagnosis but is less useful for acute clinical management. Early diagnosis is important because prompt antimicrobial therapy significantly improves outcomes.

Symptoms
Legionella pneumophila infection most commonly occurs following inhalation of contaminated aerosols generated from water systems. After an incubation period of approximately two to ten days, Legionnaires' disease typically presents with high fever, chills, cough, shortness of breath, fatigue, headache, muscle aches, and malaise. Gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain are common and may help distinguish Legionnaires' disease from other causes of pneumonia. Neurological manifestations including confusion, disorientation, and altered mental status may also occur. Severe infections can progress to respiratory failure, septic shock, multi-organ dysfunction, and death, particularly in elderly individuals, smokers, immunocompromised patients, and those with chronic underlying diseases. Pontiac fever presents as a milder influenza-like illness without pneumonia and generally resolves spontaneously within several days.

Data

FAQ & Publications

Frequently Asked Questions

What is the recommended storage condition for the Legionella pneumophila IgM Control Serum BC106M?

The Legionella pneumophila IgM Control Serum BC106M should be stored at 2-8°C to maintain its stability and performance.

Can the Legionella pneumophila IgM Control Serum BC106M be used directly in ELISA assays?

Yes, the control serum is ready-to-use and pre-diluted specifically for SERION ELISA classic and SERION ELISA antigen assays.

What is the target specificity of the Legionella pneumophila IgM Control Serum BC106M?

This control serum targets Legionella pneumophila reactive IgM antibodies, making it suitable for assays detecting this pathogen.

Is the Legionella pneumophila IgM Control Serum BC106M intended for diagnostic or research use?

The product is labeled for research use only (RUO) and is not intended for diagnostic purposes.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
BC106M protocol

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Legionella pneumophila IgM Control Serum BC106M

Data

FAQ & Publications

Protocols

Documents

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