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Bordetella pertussis IgM ELISA kit-SERION classic ESR120M

$364.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Bordetella pertussis IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR120M Category: Virion/Serion kits Tags: Bordetella pertussis, ELISA, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Bordetella pertussis reactive IgM
species reactivity	Bordetella pertussis (whooping cough)
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Bordetella pertussis IgM ELISA Kit ESR120M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

target relevance

human antibody anti-Bordetella pertussis

Bordetella pertussis

Description
Bacterium that causes whooping cough (pertussis)

Structure
Bordetella pertussis is a small, Gram-negative, aerobic coccobacillus belonging to the family Alcaligenaceae. The bacterium is a strictly human pathogen and the primary causative agent of pertussis, commonly known as whooping cough. B. pertussis colonizes the ciliated epithelium of the upper respiratory tract through the action of multiple adhesins, including filamentous hemagglutinin, pertactin, and fimbriae. The organism produces several virulence factors, most notably pertussis toxin, adenylate cyclase toxin, and tracheal cytotoxin, which interfere with host immune responses and contribute to respiratory tract damage. Despite widespread vaccination programs, Bordetella pertussis remains a significant cause of respiratory disease worldwide, particularly among infants and inadequately vaccinated populations.

Diagnosis
The diagnosis of Bordetella pertussis infection is performed using microbiological, molecular, and serological methods. Polymerase chain reaction (PCR) testing of nasopharyngeal specimens is the preferred laboratory method during the early stages of infection due to its high sensitivity and rapid turnaround time. Culture of B. pertussis from nasopharyngeal swabs remains the definitive diagnostic method but is less sensitive and requires specialized media and prolonged incubation. Serological assays, including ELISA-based tests that detect antibodies against pertussis toxin and other bacterial antigens, are useful in later stages of disease when bacterial shedding has decreased. Laboratory diagnosis is particularly important because clinical presentation may overlap with other respiratory infections.

Symptoms
Bordetella pertussis infection is highly contagious and spreads through respiratory droplets generated during coughing or sneezing. Following an incubation period of approximately seven to ten days, disease typically progresses through three stages. The catarrhal stage resembles a common upper respiratory infection with symptoms including runny nose, mild fever, sneezing, and occasional cough. This is followed by the paroxysmal stage, characterized by severe repetitive coughing fits that may be followed by the characteristic inspiratory 'whoop,' post-tussive vomiting, and exhaustion. In infants, apnea may occur and can be life-threatening. The final convalescent stage involves gradual recovery over weeks to months, although coughing episodes may persist. Complications include pneumonia, seizures, encephalopathy, rib fractures, and, particularly in young infants, death.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Bordetella pertussis IgM ELISA Kit ESR120M?

The Bordetella pertussis IgM ELISA Kit ESR120M is compatible with serum, plasma, and whole blood samples for the detection of Bordetella pertussis reactive IgM antibodies.

Why is the use of RF-Absorbent Z200 recommended with this IgM ELISA kit?

RF-Absorbent Z200 is recommended for pretreatment of samples to remove IgM rheumatoid factors, which can interfere with the assay and potentially cause false negative results, thereby improving the specificity of IgM detection in the ELISA.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR120M protocol

Documents

#
EP0148	Safety Data Sheet	QC certificate

Reviews

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Bordetella pertussis IgM ELISA kit-SERION classic ESR120M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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