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Borrelia burgdorferi IgM ELISA kit-SERION classic ESR121M

$364.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Borrelia burgdorferi IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR121M Category: Virion/Serion kits Tags: Borrelia, ELISA, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Borrelia burgdorferi reactive IgM
species reactivity	Borrelia burgdorferi (lyme disease)
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Borrelia burgdorferi IgM ELISA Kit ESR121M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

target relevance

human antibody anti-Borrelia burgdorferi

Borrelia burgdorferi

Description
Spirochete bacterium that causes Lyme borreliosis (Lyme disease)

Structure
Borrelia burgdorferi is a Gram-negative, highly motile spirochete belonging to the Borrelia burgdorferi sensu lato complex and the family Spirochaetaceae. The bacterium possesses a distinctive helical morphology and periplasmic flagella that enable corkscrew-like movement through host tissues and extracellular matrices. Borrelia burgdorferi is transmitted primarily through the bite of infected Ixodes ticks, including Ixodes scapularis and Ixodes pacificus in North America. The organism is maintained in nature through complex transmission cycles involving ticks and reservoir hosts such as rodents, birds, and other small mammals. Following inoculation into the skin, B. burgdorferi can disseminate through the bloodstream and lymphatic system to multiple organs, including the joints, heart, skin, and nervous system. It is the principal causative agent of Lyme disease in North America and one of the most extensively studied tick-borne bacterial pathogens.

Diagnosis
The diagnosis of Borrelia burgdorferi infection is performed through a combination of clinical assessment, serological testing, and molecular methods. Laboratory diagnosis typically follows a two-tier testing strategy consisting of an initial ELISA or immunoassay followed by confirmatory immunoblot testing when appropriate. Detection of Borrelia-specific IgM and IgG antibodies provides evidence of infection, although antibody responses may not be detectable during the earliest stages of disease. Polymerase chain reaction (PCR) assays may be used to detect Borrelia DNA in synovial fluid, skin biopsies, cerebrospinal fluid, and other clinical specimens. Clinical findings, exposure history, and laboratory results are interpreted together because no single diagnostic test is sufficient in all stages of disease. Early diagnosis is important because prompt antimicrobial treatment can prevent progression to disseminated infection.

Symptoms
Borrelia burgdorferi infection typically begins with localized Lyme disease following the bite of an infected tick. The most characteristic early manifestation is erythema migrans, an expanding skin lesion that develops days to weeks after exposure and may be accompanied by fever, fatigue, headache, muscle aches, and joint pain. If untreated, the infection may disseminate and involve multiple organ systems. Neurological manifestations can include meningitis, facial nerve palsy, radiculoneuritis, and peripheral neuropathy. Cardiac involvement may result in Lyme carditis with conduction abnormalities and arrhythmias. Late-stage disease commonly presents with intermittent or persistent arthritis, particularly affecting large joints such as the knee. Some patients may experience prolonged fatigue, musculoskeletal discomfort, and cognitive symptoms following treatment, although the mechanisms underlying these persistent symptoms remain an area of ongoing investigation.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Borrelia burgdorferi IgM ELISA Kit ESR121M for detecting IgM antibodies?

The Borrelia burgdorferi IgM ELISA Kit ESR121M is suitable for use with serum, plasma, and whole blood samples to detect IgM antibodies.

Why is pretreatment of samples with RF-Absorbent Z200 recommended when using this IgM ELISA kit?

Pretreatment with RF-Absorbent Z200 is recommended to remove IgM rheumatoid factors from serum and plasma samples prior to testing. This step helps eliminate potential false negative results and improves signal specificity in the detection of pathogen-specific IgM antibodies.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR121M protocol

Documents

#
ER0003	Safety Data Sheet	QC certificate

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Borrelia burgdorferi IgM ELISA kit-SERION classic ESR121M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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