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Echovirus IgM ELISA kit-SERION classic ESR135M

$364.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Echovirus IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR135M Category: Virion/Serion kits Tags: Echovirus, ELISA, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Echovirus reactive IgM
species reactivity	Echovirus
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Echovirus IgM ELISA Kit ESR135M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

Associated products
Echovirus Antigen (BA135VS01)
Echovirus IgA Control Serum (BC135A)
Echovirus IgG Control Serum (BC135G)
Echovirus IgM Control Serum (BC135M)
Echovirus IgG ELISA Kit (ESR135G)
Echovirus IgA ELISA Kit (ESR135A)
Echovirus IgM ELISA Kit (ESR135M)

target relevance

human antibody anti-Echovirus

Echovirus

Description
Group of enteroviruses that cause aseptic meningitis, febrile illness, and other systemic infections

Structure
Echoviruses (Enteric Cytopathic Human Orphan viruses) are non-enveloped, positive-sense, single-stranded RNA viruses belonging to the genus Enterovirus within the family Picornaviridae. The viruses possess an icosahedral capsid that protects the viral genome and contributes to their resistance to environmental conditions and many disinfectants. Echoviruses are transmitted primarily through the fecal-oral route, respiratory secretions, and direct contact with contaminated surfaces. Following infection, viral replication occurs in the gastrointestinal tract and upper respiratory tract before dissemination through the bloodstream to various tissues and organs. More than thirty echovirus serotypes have been identified, and they are distributed worldwide. Echoviruses are among the most common causes of enteroviral infections and are frequently associated with outbreaks in children, although infections occur in all age groups.

Diagnosis
The diagnosis of echovirus infection is performed through molecular, virological, and serological methods. Reverse transcription polymerase chain reaction (RT-PCR) is the preferred diagnostic method due to its high sensitivity and specificity and can detect viral RNA in cerebrospinal fluid, stool samples, throat swabs, blood, and other clinical specimens. Viral culture may be performed in specialized laboratories but has largely been supplanted by molecular testing. Serological assays can detect echovirus-specific antibodies and may be useful for epidemiological investigations or retrospective diagnosis. Laboratory confirmation is particularly important in patients presenting with meningitis, encephalitis, neonatal infections, myocarditis, or unexplained febrile illness.

Symptoms
Echovirus infections produce a broad spectrum of clinical manifestations ranging from asymptomatic infection to severe systemic disease. Common symptoms include fever, headache, sore throat, fatigue, muscle aches, nausea, vomiting, abdominal pain, and rash. Echoviruses are a major cause of aseptic meningitis, which typically presents with fever, severe headache, neck stiffness, photophobia, and cerebrospinal fluid pleocytosis. Less commonly, echoviruses may cause encephalitis, myocarditis, pericarditis, hepatitis, conjunctivitis, and neonatal sepsis-like illness. Newborns and immunocompromised individuals are at increased risk of severe disease, which may result in multi-organ involvement and significant morbidity. Most infections are self-limiting and resolve without long-term complications.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Echovirus IgM ELISA Kit ESR135M for detecting Echovirus reactive IgM?

The Echovirus IgM ELISA Kit ESR135M is compatible with serum, plasma, and whole blood samples for the detection of Echovirus reactive IgM antibodies.

Why is pretreatment with RF-Absorbent Z200 recommended when using the Echovirus IgM ELISA Kit?

Pretreatment of samples with RF-Absorbent Z200 is recommended to remove IgM rheumatoid factors from serum and plasma samples, which helps to eliminate potential false negative results and improves signal specificity during IgM detection.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR135M protocol

Documents

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Echovirus IgM ELISA kit-SERION classic ESR135M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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