Immunohistochemistry (IHC) : Human lymph node stained with anti-OCT-2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of follicular center B cells.

mouse anti-OCT-2 monoclonal antibody (ZM90) 6298

Price range: $160.00 through $528.00

Antibody summary

Mouse monoclonal to OCT-2
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG1
Control: B-cell lymphoma
Visualization: Nuclear
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

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SKU: 6298parent Category: antibody Tags: anatomy, Hematopathology, OCT-2

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG1
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

mouse anti-OCT-2 monoclonal antibody ZM90 6298

antibody
Database link: human P09086
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Application Notes Positive control: B-cell lymphoma
Immunogen Recombinant human OCT2 protein fragment (around aa 112-297)
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG1
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control Mouse monoclonal IgG1 - Isotype Control

target relevance
Protein names POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)
Gene names POU2F2,POU2F2 OCT2 OTF2
Protein family POU transcription factor family, Class-2 subfamily
Mass 51209Da
Function FUNCTION: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250\|UniProtKB:Q00196, ECO:0000269\|PubMed:10480874, ECO:0000269\|PubMed:2328728, ECO:0000269\|PubMed:2901913, ECO:0000269\|PubMed:2904654, ECO:0000269\|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269\|PubMed:1739980}.
Subellular location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus.
Tissues TISSUE SPECIFICITY: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. {ECO:0000269\|PubMed:2904654, ECO:0000269\|PubMed:3072196}.
Structure SUBUNIT: Interacts with NR3C1, AR and PGR (PubMed:10480874). Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity (PubMed:7859290). {ECO:0000269\|PubMed:10480874, ECO:0000269\|PubMed:7859290}.
Target Relevance information above includes information from UniProt accession: P09086
The UniProt Consortium

Data

Human lymph node stained with anti-OCT-2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of follicular center B cells.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.