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Yersinia IgA Control Serum BC138A

$94.00

Summary

  • Virion/Serion Diagnostic Kit Control for research use (RUO)
  • Yersinia IgA Control Serum
  • Applications: ELISA
  • IgA control serum
  • Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
  • 3 mL
Weight1 lbs
Dimensions9 × 5 × 2 in
target

Yersinia reactive IgA

species reactivity

Yersinia

applications

ELISA

assay type

Indirect & quantitative

available size

3 mL

Available product – Yersinia IgA Control Serum BC138A

kit
Research area
Infectious Disease
Storage
Store at 2-8°C.
Associated products
Yersinia enterocolitica o-8 YOP (Yersinia outer proteins) Antigen (BA13808VS)
Yersinia enterocolitica o-9 YOP (Yersinia outer proteins) Antigen (BA13809VS)
Yersinia enterocolitica o-3 YOP (Yersinia outer proteins) Antigen (BA138VS)
Yersinia IgA Control Serum (BC138A)
Yersinia IgG Control Serum (BC138G)
Yersinia IgM Control Serum (BC138M)
Yersinia IgA ELISA Kit (ESR138A)
Yersinia IgG ELISA Kit (ESR138G)
Yersinia IgM ELISA Kit (ESR138M)
target relevance
Organism
Yersinia enterocolitica
Structure and strains
Yersinia enterocolitica is a Gram-negative, rod-shaped bacterium, belonging to the family Yersiniaceae. It is motile at temperatures of 22 29°C (72 84°F), but becomes nonmotile at normal human body temperature. Y. enterocolitica infection causes the disease yersiniosis, which is an animal-borne disease occurring in humans, as well as in a wide array of animals such as cattle, deer, pigs, and birds. Many of these animals recover from the disease and become carriers; these are potential sources of contagion despite showing no signs of disease. The bacterium infects the host by sticking to its cells using trimeric autotransporter adhesins.
Disease
Yersinia are distributed globally in temperate and subtropical areas. The gram-negative bacteria express a range of plasmidencoded virulence factors, referred to as Yersinia Outer Proteins (YOPs). These molecules influence signal cascades within cells and inhibit the immune response of the host.

The human pathogenic bacteria Y. enterocolitica and Y. pseudotuberculosis may cause inflammation of the intestine (enteritis) associated with stomach pain, diarrhea and vomiting. The disease symptoms are often difficult to distinguish from appendicitis (pseudoappendicitis). Possible postinfectious sequelae include reactive arthritis and erythema nodosum. These complications are frequently apparent in individuals carrying the HLA-B27 gene. Furthermore, cases of acute glomerulonephritis and myocarditis have been described. In patients with weakened immune systems, the disease may take a septic course.
Detection and diagnosis
The use of sensitive and specific ELISA with quantitative determination of IgG, IgM and IgA antibodies is the method of choice for a clear differentiation between acute and chronic yersiniosis. The determination of the individual antibody activities is important for the differential diagnosis of post-infectious sequelae such as rheumatoid arthritis or erythema nodosum. Following the normal course of an acute Yersinia infection, IgG antibody activity often persists for several years while the IgA and IgM antibody activities decrease within a few months post infection. By contrast, in the case of postinfection complications, the IgA antibody activity remains elevated for years.

Data

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product
BC138A protocol

Documents

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