| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | Enterovirus reactive IgA |
| species reactivity | Enterovirus |
| applications | ELISA |
| assay type | Indirect & quantitative |
| available size | 3 mL |
Enterovirus IgA Control Serum BC133A
$94.00
Summary
- Virion/Serion Diagnostic Kit Control for research use (RUO)
- Enterovirus IgA Control Serum
- Applications: ELISA
- IgA control serum
- Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
- 3 mL
Enterovirus IgA Control Serum BC133A
| kit |
|---|
| Research area Infectious Disease |
| Storage Store at 2-8°C. |
| Associated products Enterovirus Antigen (BA133VS01) Enterovirus IgA Control Serum (BC133A) Enterovirus IgG Control Serum (BC133G) Enterovirus IgM Control Serum (BC133M) Enterovirus IgA ELISA Kit (ESR133A) Enterovirus IgG ELISA Kit (ESR133G) Enterovirus IgM ELISA Kit (ESR133M) |
| target relevance |
|---|
| Organism Enterovirus |
| Structure and strains Enterovirus is a genus of positive-sense single-stranded RNA viruses associated with several human and mammalian diseases. Enteroviruses are named by their transmission-route through the intestine ('enteric' meaning intestinal). Serologic studies have distinguished 71 human enterovirus serotypes on the basis of antibody neutralization tests. Additional antigenic variants have been defined within several of the serotypes on the basis of reduced or nonreciprocal cross-neutralization between variant strains. On the basis of their pathogenesis in humans and animals, the enteroviruses were originally classified into four groups, polioviruses, Coxsackie A viruses (CA), Coxsackie B viruses (CB), and echoviruses, but it was quickly realized that there were significant overlaps in the biological properties of viruses in the different groups. Enteroviruses isolated more recently are named with a system of consecutive numbers: EV-D68, EV-B69, EV-D70, EV-A71, etc., where genotyping is based on the VP1 capsid region. Enteroviruses affect millions of people worldwide each year and are often found in the respiratory secretions (e.g., saliva, sputum, or nasal mucus) and stool of an infected person. Historically, poliomyelitis was the most significant disease caused by an enterovirus, namely poliovirus. There are 81 non-polio and 3 polio enteroviruses that can cause disease in humans. Of the 81 non-polio types, there are 22 Coxsackie A viruses, 6 Coxsackie B viruses, 28 echoviruses, and 25 other enteroviruses. |
| Disease The pathogenic Enteroviruses consist of some 60 serotypes of which the Cosackieviruses, ECHO viruses and Enteroviruses serotypes 70 and 71 are of particular significance for humans. The surface of the icosahedral virus capsid consists of the structural proteins VP1, VP2 and VP3, which are responsible for the antigenic properties and the division into the various serotypes. Transmission of the virus between hosts occurs primarily by direct contact or droplet infection. In addition, the virus may be transmitted via the placenta. The incubation period is generally 3 to 5 days. Some 90 to 95% of all Enterovirus infections are asymptomatic or manifest with unspecific febrile symptoms and are therefore frequently not identified. The illnesses which may result from Enterovirus infection are numerous and include upper respiratory tract infection (summer flu), pneumonia, pleurodynia, herpangina, hand, foot and mouth disease, febrile generalised exanthems, conjunctivitis, gastroenteritis, Bornholm disease, hepatitis, myocarditis, pericarditis, meningitis, encephalitis, paralysis, and fetal damage with possible perinatal disease including pneumonia, myocarditis and meningoencephalitis. Infections with Enteroviruses occur throughout the year but do show a seasonal increase during the summer and autumn months in temperate regions. |
| Detection and diagnosis The demonstration of infection by the detection of specific antibodies generally requires the analysis of serum pairs. A positive result for IgM or IgA combined with rising IgG activity serves as clear evidence of an acute or recent infection. Persisting IgM and IgA antibody levels are frequently observed in chronic infections. |
Publications
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