Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human solitary fibrous tumor stained with anti-STAT6 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear and cytoplasmic staining of tumor cells

rabbit anti-STAT6 monoclonal antibody (ZR289) 6369

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to STAT6
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Solitary fibrous tumor
Visualization: Nuclear
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

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SKU: 6369parent Category: antibody Tags: anatomy, Soft Tissue Pathology, STAT6

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-STAT6 monoclonal antibody ZR289 6369

antibody
Database link: human P42226
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Application Notes Positive control: Solitary fibrous tumor
Immunogen Recombinant full-length human STAT6 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Signal transducer and activator of transcription 6 (IL-4 Stat)
Gene names STAT6,STAT6
Protein family Transcription factor STAT family
Mass 94135Da
Function FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269\|PubMed:17210636, ECO:0000269\|PubMed:36758835, ECO:0000269\|PubMed:36884218}.
Subellular location SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000269\|PubMed:36758835}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000269\|PubMed:36758835}.
Structure SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif. {ECO:0000250, ECO:0000269\|PubMed:12138096, ECO:0000269\|PubMed:14757047}.
Post-translational modification PTM: Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636). {ECO:0000250\|UniProtKB:P52633, ECO:0000269\|PubMed:17210636, ECO:0000269\|PubMed:27796300}.; PTM: Mono-ADP-ribosylated by PARP14. {ECO:0000269\|PubMed:27796300}.
Involvement in disease DISEASE: Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections (HIES6) [MIM:620532]: An immunologic disorder characterized by severe allergic disease with onset in infancy. Common features are treatment-resistant atopic dermatitis, food allergies, asthma, eosinophilic gastrointestinal disease, and severe episodes of anaphylaxis. Half of the patients present with recurrent skin, respiratory, and viral infections. Clinical laboratory testing is notable for eosinophilia and markedly elevated serum IgE levels. {ECO:0000269\|PubMed:36758835, ECO:0000269\|PubMed:36884218, ECO:0000269\|PubMed:37316763}. Note=The disease is caused by variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: P42226
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human solitary fibrous tumor stained with anti-STAT6 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear and cytoplasmic staining of tumor cells

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.