| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | mouse |
| isotype | IgG |
| clonality | monoclonal |
| concentration | concentrate, predilute |
| applications | IHC |
| reactivity | human |
| available size | 0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted |
rabbit anti-OCT-2 monoclonal antibody (ZR227) 6297
$160.00 – $528.00
Antibody summary
- Rabbit monoclonal to OCT-2
- Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
- Reacts with: Human
- Isotype:IgG
- Control: B-cell lymphoma
- Visualization: Nuclear
- 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
rabbit anti-OCT-2 monoclonal antibody ZR227 6297
| target relevance |
|---|
| Protein names POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) |
| Protein family POU transcription factor family, Class-2 subfamily |
| Mass 51209Da |
| Function Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874).; [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. |
| Subellular location Cytoplasm . Nucleus. |
| Tissues Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. |
| Structure Interacts with NR3C1, AR and PGR (PubMed:10480874). Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity (PubMed:7859290). |
| Domain DOMAIN 195..269; /note="POU-specific"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00530" |
| Target Relevance information above includes information from UniProt accession: P09086 |
| The UniProt Consortium |
|
| Formalin-fixed, paraffin-embedded human lymph node stained with anti-OCT2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of follicular B cells |
Publications
| pmid | title | authors | citation |
|---|---|---|---|
| We haven't added any publications to our database yet. | |||
| relevant to this product |
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| IHC |
| # | SDS | Certificate | |
|---|---|---|---|
| Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information. | |||
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