Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | mouse |
isotype | IgG |
clonality | monoclonal |
concentration | concentrate, predilute |
applications | IHC |
reactivity | human |
available size | 0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted |
rabbit anti-NKX3.1 monoclonal antibody (ZR222) 6292
$160.00 – $528.00
Antibody summary
- Rabbit monoclonal to NKX3.1
- Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
- Reacts with: Human
- Isotype:IgG
- Control: Prostate
- Visualization: Nuclear
- 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
rabbit anti-NKX3.1 monoclonal antibody ZR222 6292
target relevance |
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Protein names Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) |
Protein family NK-3 homeobox family |
Mass 26350Da |
Function Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. . |
Subellular location Nucleus . |
Tissues Highly expressed in the prostate and, at a lower level, in the testis. . |
Structure Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF (PubMed:11809674). Interacts with WDR77 (PubMed:12972618). Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation (PubMed:18077445). Interacts with FEM1B (By similarity). . |
Post-translational modification PTM: Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues. . |
Target Relevance information above includes information from UniProt accession: Q99801 |
The UniProt Consortium |
Data
Formalin-fixed, paraffin-embedded prostate adenocarcinoma stained with anti-NKX3.1 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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IHC |
Documents
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