Immunohistochemistry (IHC) : Human skin stained with anti-CD1a antibody using peroxidase-conjugate and DAB chromogen. Note membrane staining of langerhan cells.

mouse anti-CD1a monoclonal antibody (O10) 6069

$160.00 – $528.00

Antibody summary

Mouse monoclonal to CD1a
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG1
Control: Skin or Langerhans cell histiocytosis X
Visualization: Cell membrane and cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6069parent Category: antibody Tags: anatomy, CD1A, Hematopathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG1
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

mouse anti-CD1a monoclonal antibody O10 6069

antibody
Database link: human P06126
Tested applications IHC
Recommended dilutions As directed
Immunogen CD1a
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG1
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control Mouse monoclonal IgG1 - Isotype Control

target relevance
Protein names T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)
Mass 37077Da
Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269\|PubMed:11231314, ECO:0000269\|PubMed:16272286, ECO:0000269\|PubMed:18178838}.
Subellular location Cell membrane {ECO:0000269\|PubMed:11231314, ECO:0000269\|PubMed:11600221, ECO:0000269\|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269\|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269\|PubMed:11231314}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). {ECO:0000269\|PubMed:11231314, ECO:0000269\|PubMed:18178838}.
Tissues Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269\|PubMed:11231314, ECO:0000269\|PubMed:18178838}.
Structure Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74. {ECO:0000269\|PubMed:12833155, ECO:0000269\|PubMed:15723809, ECO:0000269\|PubMed:18178838}.
Target Relevance information above includes information from UniProt accession: P06126
The UniProt Consortium

Data

Human skin stained with anti-CD1a antibody using peroxidase-conjugate and DAB chromogen. Note membrane staining of langerhan cells.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.