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Helicobacter pylori IgM ELISA kit-SERION classic ESR118M

$398.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Helicobacter pylori IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR118M Category: Virion/Serion kits Tags: ELISA, Helicobacter pylori, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Helicobacter pylori reactive IgM
species reactivity	Helicobacter pylori
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Helicobacter pylori IgM ELISA Kit ESR118M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

Associated products
Helicobacter pylori Antigen (BA118VS)
Helicobacter pylori IgA Control Serum (BC118A)
Helicobacter pylori IgG Control Serum (BC118G)
Helicobacter pylori IgM Control Serum (BC118M)
Helicobacter pylori IgA ELISA Kit (ESR118A)
Helicobacter pylori IgG ELISA Kit (ESR118G)
Helicobacter pylori IgM ELISA Kit (ESR118M)

target relevance

human antibody anti-Helicobacter pylori

Helicobacter pylori

Description
Bacterium that causes gastritis, peptic ulcer disease, and gastric cancer

Structure
Helicobacter pylori is a Gram-negative, microaerophilic, spiral-shaped bacterium belonging to the family Helicobacteraceae. The organism is uniquely adapted to colonize the human stomach and is capable of surviving the highly acidic gastric environment through the production of urease, an enzyme that converts urea into ammonia and carbon dioxide, creating a protective alkaline microenvironment. H. pylori possesses multiple flagella that enable motility through the gastric mucus layer and adherence to gastric epithelial cells. The bacterium is one of the most common chronic bacterial infections worldwide and is recognized as a major cause of chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma.

Diagnosis
The diagnosis of Helicobacter pylori infection can be performed using invasive and non-invasive methods. Non-invasive tests include urea breath tests, stool antigen assays, and serological detection of H. pylori-specific antibodies. The urea breath test and stool antigen assays are highly sensitive and specific and are commonly used for both diagnosis and confirmation of eradication following treatment. Invasive diagnostic methods involve upper gastrointestinal endoscopy with gastric biopsy for histological examination, rapid urease testing, culture, or molecular detection by polymerase chain reaction (PCR). Serological assays, including ELISA-based methods, are useful for epidemiological studies and assessment of previous exposure but may not reliably distinguish active from past infection.

Symptoms
Helicobacter pylori infection is often acquired during childhood and may persist for life if untreated. Many infected individuals remain asymptomatic; however, chronic infection can lead to inflammation of the gastric mucosa and the development of gastrointestinal disease. Common symptoms include upper abdominal pain or discomfort, nausea, bloating, early satiety, excessive belching, and indigestion. In patients with peptic ulcer disease, symptoms may include burning epigastric pain, gastrointestinal bleeding, vomiting, or anemia. Long-term infection increases the risk of gastric atrophy, intestinal metaplasia, gastric adenocarcinoma, and MALT lymphoma. Eradication of H. pylori significantly reduces the risk of ulcer recurrence and certain gastric malignancies.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Helicobacter pylori IgM ELISA Kit ESR118M for detecting IgM antibodies?

The Helicobacter pylori IgM ELISA Kit ESR118M is compatible with serum, plasma, and whole blood samples for the detection of Helicobacter pylori reactive IgM antibodies.

Why is the use of RF-Absorbent Z200 recommended when performing the Helicobacter pylori IgM ELISA Kit assay?

RF-Absorbent Z200 is recommended for pretreatment of samples to remove IgM rheumatoid factors, which can interfere with the assay and cause false negative results, thereby improving signal specificity in the detection of pathogen-specific IgM.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR118M protocol

Documents

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Helicobacter pylori IgM ELISA kit-SERION classic ESR118M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

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Reviews

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