| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | Leptospira biflexa |
| species reactivity | Leptospira |
| applications | ELISA |
| assay type | Indirect & quantitative |
| available size | 1 mg |
Leptospira biflexa Antigen BA125VS
$913.00
Summary
- Virion/Serion Immunologics Antigen for research use (RUO)
- Leptospira biflexa Antigen, recombinant
- Suitable for detection of IgA, IgG & IgM antibodies in ELISA
- Lot specific concentration, specified in mg/mL
- 1 mg
Leptospira biflexa Antigen BA125VS
| kit |
|---|
| Research area Infectious Disease |
| Storage Store at -65°C or lower. Avoid repeated freeze-thaw cycles. Sonicate before use. 10 years from date of manufacture (under recommended storage conditions). |
| Form liquid |
| Associated products Leptospira biflexa Antigen (BA125VS) Leptospira IgG Control Serum (BC125G) Leptospira IgM Control Serum (BC125M) Leptospira IgG ELISA Kit (ESR125G) Leptospira IgM ELISA Kit (ESR125M) |
| target relevance |
|---|
| Organism Leptospira species |
| Structure and strains Leptospira is a genus of spirochaete bacteria, including a small number of pathogenic and saprophytic species. Leptospira was first observed in 1907 in kidney tissue slices of a leptospirosis victim who was described as having died of "yellow fever". |
| Disease Leptospirosis is an infectious disease which occurs worldwide and is caused by bacteria of the genus Leptospira. More than 250 serovars have been identified and grouped into 24 serovars on the basis of their surface antigens. Wild and domesticated animals act as reservoirs for this pathogen. Leptospira can survive for extended periods in the kidney tubules of infected animals and are excreted in the urine. Transmission to humans occurs by contact with urine, blood or tissues of infected animals, and contaminated water. The bacteria gain access to the body via skin lesions or contact with mucous membranes. which occurs worldwide and is caused by bacteria of the genus Leptospira. More than 250 serovars have been identified and grouped into 24 serovars on the basis of their surface antigens. Wild and domesticated animals act as reservoirs for this pathogen. Leptospira can survive for extended periods in the kidney tubules of infected animals and are excreted in the urine. Transmission to humans occurs by contact with urine, blood or tissues of infected animals, and contaminated water. The bacteria gain access to the body via skin lesions or contact with mucous membranes. Disease Replication of the bacterium proceeds primarily in organs (e.g. kidneys and liver) as well as the central nervous system. As a consequence, infections are frequently misdiagnosed as meningitis or hepatitis from other causes. Approximately 90% of cases of leptospirosis are accompanied by flu-like symptoms including the sudden onset of fever, severe headache, muscle ache and nausea. A biphasic course of disease is characteristic for a Leptospira infection. In severe cases called Morbus Weil Disease, liver and kidney damages may lead to a morbidity rate of 30% if left untreated. |
| Detection and diagnosis During the initial disease phase, isolation of leptospira from blood samples is possible. However, cultivation of the pathogen is often too time-consuming to allow for an effective antibiotic treatment. Consequently, diagnosis based on antibody detection such as Microagglutination tests (Gold Standard), CFT or ELISA is more frequently employed to affect a more rapid diagnosis of Leptospira infections. Once the second disease phase has started, the only effective diagnostic methodology is serology. IgM and IgG are detectable for a considerable period, however, less than 90% of patients actually produce IgG antibodies. |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.| pmid | title | authors | citation |
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Protocols
| relevant to this product |
|---|
| BA125VS protocol |
Documents
| Product data sheet |
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| BA125VS |
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