| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | TBE |
| species reactivity | For the detection of Tick Borne Encephalitis Virus |
| applications | RT PCR |
| assay type | direct & qualitative |
| available sizes | 96 tests |
TBE RT-PCR test Mikrogen 830519
$487.00
Summary
- Mikrogen diagnostik RT PCR kit for research use (RUO)
- Direct TBE virus detection
- High sensitivity and specificity
- Internal control for monitoring nucleic acid extraction
(RNA/DNA) and real-time PCR inhibition in each reaction - Compatible with most common real-time PCR cyclers & RNA/DNA extraction methods
- 96 tests
TBE RT-PCR test Mikrogen 830519
| kit | |||||||||||||||
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| Assay type RT PCR | |||||||||||||||
| Research area Infectious Disease | |||||||||||||||
| Sample type whole blood, serum, plasma, urine, tissue, stool, etc., food and environmental samples or from the carrier material | |||||||||||||||
Notes
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Components
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| Storage Store at -20°C. | |||||||||||||||
| Additional information Highly sensitive and specific direct detection of pathogens that can cause tick-borne infections
Applicable to human starting material as well as RNA/DNA from the tick |
| target relevance |
|---|
| Organism Tick-Borne Encephalitis Virus (FSME/TBE Virus) |
| Structure and strains Tick-borne encephalitis virus (TBEV) is a positive-strand RNA virus associated with tick-borne encephalitis in the genus Flavivirus. |
| Disease TBE Viruses can be transmitted to humans by infected ticks and may cause the so called tick-borne encephalitis (TBE). They belong to the human pathogenic species among the flaviviruses. Of particular note is the highly immunogenic envelope protein E, embedded in the surface of the virus. TBE Viruses are distributed throughout Europe and Asia. Depending upon their distribution, the three TBE Virus variants are referred to as the Central European, Siberian or Far Eastern subtype. The majority of TBE Virus infections remain clinically asymptomatic. In 30% of cases, a biphasic course of disease starts with the onset of flu-like symptoms following an incubation period of 7 to 14 days. After a fever-free interval of one week, 10% of patients go on to develop encephalitis or meningoencephalitis, occasionally with long-lasting neurological symptoms. The majority of patients recover fully, even when the infection takes a severe course. However, there is a morbidity rate of around 1% for patients with CNS involvement. A naturally aquired infection usually leads to life-long immunity. In contrast, immunization results in limited immune protection and should be refreshed at regular intervals. |
| Detection and diagnosis Cultivation of the TBE Virus is complex, time consuming and requires special safety precautions. Direct pathogen detection by RT-PCR is possible at the onset of disease, however, a negative result does not rule out a TBE Virus infection. As a consequence, the determination of pathogen-specific antibodies by ELISA is recommended for laboratory confirmation of TBE Virus infections. The combined demonstration of IgG and IgM antibodies directed against TBE Virus, a significant increase in antibody activity by the analysis of serum pairs or the detection of intrathecally synthesized IgG or IgM antibodies serve to confirm an infection. |
Data
| No results found |
Publications
Publications
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| We haven't added any publications to our database yet. | |||
Protocols
| relevant to this product |
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| 830519 protocol |
Documents
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| Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information. | ||
