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rabbit anti-SALL4 monoclonal antibody (ZR276) 6360

$160.00$528.00

Antibody summary

  • Rabbit monoclonal to SALL4
  • Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
  • Reacts with: Human
  • Isotype:IgG
  • Control: Seminoma
  • Visualization: Nuclear
  • 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
SKU: 6360parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

mouse

isotype

IgG

clonality

monoclonal

concentration

concentrate, predilute

applications

IHC

reactivity

human

available size

0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-SALL4 monoclonal antibody ZR276 6360

antibody
Database link:
human O14601
Tested applications
IHC
Recommended dilutions
Concentrated 1:100-200
Applicaiton Notes
Positive control: Seminoma
Immunogen
Recombinant fragment (around aa1-185) of human MIC2 protein (exact sequence is proprietary)
Size and concentration
7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form
liquid
Storage Instructions
2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity
affinity purified
Clonality
monoclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
Protein names
Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4)
Gene names
SALL4,SALL4 ZNF797
Protein family
Sal C2H2-type zinc-finger protein family
Mass
112231Da
Tissues
TISSUE SPECIFICITY: Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML). {ECO:0000269|PubMed:16763212}.
Structure
SUBUNIT: Interacts with POU5F1/OCT4 (PubMed:23012367). Interacts with NANOG (By similarity). Interacts with BEND3 (PubMed:21914818). Interacts with NSD2 (via PHD-type zinc fingers 1, 2 and 3) (By similarity). Interacts with NRBP1 (PubMed:22510880). {ECO:0000250|UniProtKB:Q8BX22, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:22510880, ECO:0000269|PubMed:23012367}.
Post-translational modification
PTM: Isoform SALL4B exists primarily as a ubiquitinated form. {ECO:0000269|PubMed:23012367}.; PTM: Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4. {ECO:0000269|PubMed:23012367}.
Involvement in disease
DISEASE: Duane-radial ray syndrome (DRRS) [MIM:607323]: Disorder characterized by the association of forearm malformations with Duane retraction syndrome. {ECO:0000269|PubMed:12393809, ECO:0000269|PubMed:12395297, ECO:0000269|PubMed:16402211}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: IVIC syndrome (IVIC) [MIM:147750]: An autosomal dominant condition characterized by upper limbs anomalies (radial ray defects, carpal bones fusion), extraocular motor disturbances, congenital bilateral non-progressive mixed hearing loss. Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney malrotation or rectovaginal fistula. The IVIC syndrome is an allelic disorder of Duane-radial ray syndrome with a similar phenotype. {ECO:0000269|PubMed:17256792}. Note=The disease is caused by variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: Q9UJQ4
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human seminoma stained with anti-SALL4 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells
Formalin-fixed, paraffin-embedded human seminoma stained with anti-SALL4 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

relevant to this product
IHC

Documents

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