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rabbit anti-NeuN polyclonal antibody 2615

(11 customer reviews)

$100.00$2,600.00

Antibody summary

  • Rabbit polyclonal to NeuN
  • Suitable for: WB, ICC/IF, IHC
  • Reacts with: human, mouse, rat
  • Isotype: IgG
  • 100 µg, 25 µg, 1 mg
SKU: 2615parent Categories: , Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

rabbit

isotype

IgG

clonality

polyclonal

concentration

1 mg/mL

applications

ICC/IF, IHC, WB

available sizes

1 mg, 100 µg, 25 µg

Available product – rabbit anti-NeuN polyclonal antibody 2615

antibody
Database link:
human A6NFN3
mouse Q8BIF2
Tested applications
WB,IHC,IHC,ICC/IF
Recommended dilutions
WB: 1:500-1:1000 IF/IHC 1:5000-1:10000
Immunogen
Peptide corresponding to amino acids 5-24 of human FOX3 coupled to KLH
Size and concentration
25, 100, 1000µg and 1 mg/mL
Form
liquid
Storage Instructions
2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Storage buffer
PBS, 50% glycerol, 0.04% NaN3
Purity
affinity purified
Clonality
polyclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
NeuN, also known as Fox-3 or RBFOX3, is a well-established neuronal marker widely used in neuroscience research. It is a nuclear protein that is selectively expressed in post-mitotic neurons, making it an essential tool for identifying and characterizing neuronal populations in various tissues and experimental models. NeuN immunohistochemistry, facilitated by specific antibodies targeting NeuN, allows researchers to visualize and quantify neuronal cell bodies, providing valuable insights into neuronal distribution, density, and morphology. This marker is particularly valuable for studying neurodevelopment, neurodegenerative diseases, and neuronal plasticity in response to different experimental conditions or treatments. Moreover, NeuN antibodies have proven instrumental in identifying and differentiating neurons from other cell types, such as glial cells, in complex neural tissues.

Click for more on: cell markers and NeuN
Protein names
RNA binding protein fox-1 homolog 3 (Fox-1 homolog C) (Neuronal nuclei antigen) (NeuN antigen)
Gene names
RBFOX3,RBFOX3
Mass
33873Da
Function
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
Subellular location
Nucleus Cytoplasm Note=Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment.
Target Relevance information above includes information from UniProt accession : A6NFN3
The UniProt Consortium

Data

ICC/IF-image-rabbit-anti-NeuN-polyclonal-antibody-2615
Immunofluorescent analysis of a rat brain section stained with rabbit pAb to FOX3/NeuN protein, 2615, dilution 1:2,000 in red, and costained with chicken pAb to microtubule associated protein 2 (MAP2), dilution 1:5,000 in green. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45µm, and free-floating sections were stained with the above antibodies. The FOX3/NeuN antibody selectively stains nuclei and cytoplasm of neuronal cells, while the MAP2 antibody labels dendrites and overlaps with Fox3/NeuN staining in neuronal perikarya.
IHC-image-rabbit-anti-NeuN-polyclonal-antibody-2615
Chromogenic immunostaining of a formalin fixed paraffin embedded mouse hippocampus section with rabbit pAb to Fox3/NeuN, 2615, dilution 1:4,000, detected with DAB (brown) using the Vector Labs ImmPRESS method and reagents with citra buffer retrieval. The 2615 antibody selectively labels the nuclei and distal perikaryal of most neuronal cell populations. This antibody performs well in testing with 4% PFA and NBF fixed mouse, human, and rat tissues. Mouse select image for larger view.
WB-image-rabbit-anti-NeuN-polyclonal-antibody-2615
Western blot analysis of cytosolic (cyt) and nuclear enriched (nuc) fractions of whole brain lysates using rabbit pAb to FOX3/NeuN N-terminal peptide, 2615, dilution 1:1,000 in green: [1] protein molecular weight standard (red), [2] rat cyt, [3] rat nuc, [4] mouse cyt, and [5] mouse nuc lysate. Two bands of 46 and 48kDa correspond to the two alternate transcripts of the FOX3/NeuN protein. Western blot was performed under non reducing conditions.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation
36312018Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imagingMaharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL, Wang N.Front Neurosci. 2022 Oct 13;16:1025457. doi: 10.3389/fnins.2022.1025457. eCollection 2022.
36291186Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 MiceRosa JG, Hamel K, Sheeler C, Borgenheimer E, Gilliat S, Soles A, Ghannoum FJ, Sbrocco K, Handler HP, Rainwater O, Kang R, Cvetanovic M.Cells. 2022 Oct 21;11(20):3323. doi: 10.3390/cells11203323.
35972048Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defectsLiang JH, Alevy J, Akhanov V, Seo R, Massey CA, Jiang D, Zhou J, Sillitoe RV, Noebels JL, Samuel MA.Dis Model Mech. 2022 Sep 1;15(9):dmm049642. doi: 10.1242/dmm.049642. Epub 2022 Sep 13.
35897768Reorganization of the Brain Extracellular Matrix in Hippocampal SclerosisSitaš B, Bobić-Rasonja M, Mrak G, Trnski S, Krbot Skorić M, Orešković D, Knezović V, Petelin Gadže Ž, Petanjek Z, Šimić G, Kolenc D, Jovanov Milošević N.Int J Mol Sci. 2022 Jul 25;23(15):8197. doi: 10.3390/ijms23158197.
35813947Plcg2(M28L) Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in MiceOblak AL, Kotredes KP, Pandey RS, Reagan AM, Ingraham C, Perkins B, Lloyd C, Baker D, Lin PB, Soni DM, Tsai AP, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Meyer JA, Peters JS, Figueiredo LL, Sasner M, Territo PR, Sukoff Rizzo SJ, Carter GW, Lamb BT, Howell GR.Front Aging Neurosci. 2022 Jun 24;14:886575. doi: 10.3389/fnagi.2022.886575. eCollection 2022.
35735912Radial Glia and Neuronal-like Ependymal Cells Are Present within the Spinal Cord of the Trunk (Body) in the Leopard Gecko (Eublepharis macularius)Donato SV, Vickaryous MK.J Dev Biol. 2022 Jun 1;10(2):21. doi: 10.3390/jdb10020021.
35656472Angelica dahurica Extracts Attenuate CFA-Induced Inflammatory Pain via TRPV1 in MiceZhu C, Wang M, Guo J, Su SL, Yu G, Yang Y, Zhou Y, Tang Z.Evid Based Complement Alternat Med. 2022 May 23;2022:4684830. doi: 10.1155/2022/4684830. eCollection 2022.
35656006Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the HippocampusDobric A, De Luca SN, Seow HJ, Wang H, Brassington K, Chan SMH, Mou K, Erlich J, Liong S, Selemidis S, Spencer SJ, Bozinovski S, Vlahos R.Front Mol Neurosci. 2022 May 17;15:893083. doi: 10.3389/fnmol.2022.893083. eCollection 2022.
35603771Prenatal development of the human entorhinal cortexŠimić G, Krsnik Ž, Knezović V, Kelović Z, Mathiasen ML, Junaković A, Radoš M, Mulc D, Španić E, Quattrocolo G, Hall VJ, Zaborszky L, Vukšić M, Olucha Bordonau F, Kostović I, Witter MP, Hof PR.J Comp Neurol. 2022 Oct;530(15):2711-2748. doi: 10.1002/cne.25344. Epub 2022 May 23.
35529519Phasic stimulation in the nucleus accumbens enhances learning after traumatic brain injuryAronson JP, Katnani HA, Huguenard A, Mulvaney G, Bader ER, Yang JC, Eskandar EN.Cereb Cortex Commun. 2022 Apr 9;3(2):tgac016. doi: 10.1093/texcom/tgac016. eCollection 2022.
35521065Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in ratsJi NN, Meng QX, Wang Y, Zhou ZM, Song Y, Hua R, Zhang YM.Neurobiol Stress. 2022 Apr 21;18:100449. doi: 10.1016/j.ynstr.2022.100449. eCollection 2022 May.
35501917Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathyBrody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM.Mol Neurodegener. 2022 May 3;17(1):32. doi: 10.1186/s13024-022-00526-y.
35445192α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosisZanganeh PF, Barton SK, Lim K, Qian EL, Crombie DE, Bye CR, Turner BJ.Brain Commun. 2022 Mar 31;4(2):fcac081. doi: 10.1093/braincomms/fcac081. eCollection 2022.
35411012Identification of lamprey variable lymphocyte receptors that target the brain vasculatureLajoie JM, Katt ME, Waters EA, Herrin BR, Shusta EV.Sci Rep. 2022 Apr 11;12(1):6044. doi: 10.1038/s41598-022-09962-8.
35370604The APOE (ε3/ε4) Genotype Drives Distinct Gene Signatures in the Cortex of Young MiceFoley KE, Hewes AA, Garceau DT, Kotredes KP, Carter GW, Sasner M, Howell GR.Front Aging Neurosci. 2022 Mar 16;14:838436. doi: 10.3389/fnagi.2022.838436. eCollection 2022.
35365898Gene expression changes in the brain of a Cushing's syndrome mouse modelAmaya JM, Viho EMG, Sips HCM, Lalai RA, Sahut-Barnola I, Dumontet T, Montanier N, Pereira AM, Martinez A, Meijer OC.J Neuroendocrinol. 2022 Apr;34(4):e13125. doi: 10.1111/jne.13125. Epub 2022 Apr 1.
35315655Deep Single-Cell-Type Proteome Profiling of Mouse Brain by Nonsurgical AAV-Mediated Proximity LabelingSun X, Sun H, Han X, Chen PC, Jiao Y, Wu Z, Zhang X, Wang Z, Niu M, Yu K, Liu D, Dey KK, Mancieri A, Fu Y, Cho JH, Li Y, Poudel S, Branon TC, Ting AY, Peng J.Anal Chem. 2022 Apr 5;94(13):5325-5334. doi: 10.1021/acs.analchem.1c05212. Epub 2022 Mar 22.
35203460Mitoquinone Helps Combat the Neurological, Cognitive, and Molecular Consequences of Open Head Traumatic Brain Injury at Chronic Time PointHaidar MA, Shakkour Z, Barsa C, Tabet M, Mekhjian S, Darwish H, Goli M, Shear D, Pandya JD, Mechref Y, El Khoury R, Wang K, Kobeissy F.Biomedicines. 2022 Jan 24;10(2):250. doi: 10.3390/biomedicines10020250.
35140584Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's DiseaseJavonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM.Front Neurosci. 2022 Jan 24;15:785276. doi: 10.3389/fnins.2021.785276. eCollection 2021.
35065054Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time pointTabet M, El-Kurdi M, Haidar MA, Nasrallah L, Reslan MA, Shear D, Pandya JD, El-Yazbi AF, Sabra M, Mondello S, Mechref Y, Shaito A, Wang KK, El-Khoury R, Kobeissy F.Exp Neurol. 2022 May;351:113987. doi: 10.1016/j.expneurol.2022.113987. Epub 2022 Jan 19.
34970124The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic NucleusBokulić E, Medenica T, Knezović V, Štajduhar A, Almahariq F, Baković M, Judaš M, Sedmak G.Front Neuroanat. 2021 Dec 14;15:749390. doi: 10.3389/fnana.2021.749390. eCollection 2021.
34930944Contributions of Na(V)1.8 and Na(V)1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neuronsAlsaloum M, Labau JIR, Liu S, Estacion M, Zhao P, Dib-Hajj F, Waxman SG.Sci Rep. 2021 Dec 20;11(1):24283. doi: 10.1038/s41598-021-03608-x.
34876621Ketogenic Diet as a potential treatment for traumatic brain injury in miceHar-Even M, Rubovitch V, Ratliff WA, Richmond-Hacham B, Citron BA, Pick CG.Sci Rep. 2021 Dec 7;11(1):23559. doi: 10.1038/s41598-021-02849-0.
34855047IPSC-Derived Human Neurons with GCaMP6s Expression Allow In Vitro Study of Neurophysiological Responses to NeurochemicalsGaliakberova AA, Surin AM, Bakaeva ZV, Sharipov RR, Zhang D, Dorovskoy DA, Shakirova KM, Fisenko AP, Dashinimaev EB.Neurochem Res. 2022 Apr;47(4):952-966. doi: 10.1007/s11064-021-03497-6. Epub 2021 Dec 2.
34854268Conditioned medium of E17 rat brain cells induced differentiation of primary colony of mice blastocyst into neuron-like cellsBudiariati V, Rinendyaputri R, Noviantari A, Haq NMD, Budiono D, Pristihadi DN, Juliandi B, Fahrudin M, Boediono A.J Vet Sci. 2021 Nov;22(6):e86. doi: 10.4142/jvs.2021.22.e86.
34844020Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissuesClaflin KE, Flippo KH, Sullivan AI, Naber MC, Zhou B, Neff TJ, Jensen-Cody SO, Potthoff MJ.Mol Metab. 2022 Jan;55:101405. doi: 10.1016/j.molmet.2021.101405. Epub 2021 Nov 26.
34829971Energy Metabolism and Intracellular pH Alteration in Neural Spheroids Carrying Down SyndromeKashirina A, Gavrina A, Kryukov E, Elagin V, Kolesova Y, Artyuhov A, Momotyuk E, Abdyyev V, Meshcheryakova N, Zagaynova E, Dashinimaev E, Kashina A.Biomedicines. 2021 Nov 22;9(11):1741. doi: 10.3390/biomedicines9111741.
34707490Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47HKotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR.Front Aging Neurosci. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524. eCollection 2021.
34654824Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's diseaseForner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM, Green KN.Sci Data. 2021 Oct 15;8(1):270. doi: 10.1038/s41597-021-01054-y.
34651338Hemispheric cortical atrophy and chronic microglial activation following mild focal ischemic stroke in adult male ratsErmine CM, Nithianantharajah J, O'Brien K, Kauhausen JA, Frausin S, Oman A, Parsons MW, Brait VH, Brodtmann A, Thompson LH.J Neurosci Res. 2021 Dec;99(12):3222-3237. doi: 10.1002/jnr.24939. Epub 2021 Oct 14.
34296154UV-Induced Neuronal Degeneration in the Rat Cerebral CortexNakata M, Shimoda M, Yamamoto S.Cereb Cortex Commun. 2021 Feb 1;2(1):tgab006. doi: 10.1093/texcom/tgab006. eCollection 2021.
34219728A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic MiceKuwar R, Rolfe A, Di L, Blevins H, Xu Y, Sun X, Bloom GS, Zhang S, Sun D.J Alzheimers Dis. 2021;82(4):1769-1783. doi: 10.3233/JAD-210400.
34212562Uroguanylin increases Ca2+ concentration in astrocytes via guanylate cyclase C-independent signaling pathwayHabek N, Ratko M, Dugandžić A.Croat Med J. 2021 Jun 30;62(3):250-263. doi: 10.3325/cmj.2021.62.250.
34206649Loss of HCN2 in Dorsal Hippocampus of Young Adult Mice Induces Specific Apoptosis of the CA1 Pyramidal Neuron LayerDeutsch M, Stegmayr C, Balfanz S, Baumann A.Int J Mol Sci. 2021 Jun 22;22(13):6699. doi: 10.3390/ijms22136699.
34143376Cannabidiol promotes neurogenesis in the dentate gyrus during an abstinence period in rats following chronic exposure to methamphetamineRazavi Y, Keyhanfar F, Haghparast A, Shabani R, Mehdizadeh M.Metab Brain Dis. 2021 Aug;36(6):1381-1390. doi: 10.1007/s11011-021-00774-9. Epub 2021 Jun 18.
34138843Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogrammingQiang Q, Manalo JM, Sun H, Zhang Y, Song A, Wen AQ, Wen YE, Chen C, Liu H, Cui Y, Nemkov T, Reisz JA, Edwards Iii G, Perreira FA, Kellems RE, Soto C, D'Alessandro A, Xia Y.PLoS Biol. 2021 Jun 17;19(6):e3001239. doi: 10.1371/journal.pbio.3001239. eCollection 2021 Jun.
34092653The Human Hippocampus in Parkinson's Disease: An Integrative Stereological and Proteomic StudyVillar-Conde S, Astillero-Lopez V, Gonzalez-Rodriguez M, Villanueva-Anguita P, Saiz-Sanchez D, Martinez-Marcos A, Flores-Cuadrado A, Ubeda-Bañon I.J Parkinsons Dis. 2021;11(3):1345-1365. doi: 10.3233/JPD-202465.
33990935Altered hippocampal kynurenine pathway metabolism contributes to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosisDey S, Banerjee Dixit A, Tripathi M, Doddamani RS, Sharma MC, Lalwani S, Chandra PS, Banerjee J.Br J Pharmacol. 2021 Oct;178(19):3959-3976. doi: 10.1111/bph.15534. Epub 2021 Jun 22.
33986303Longitudinal hippocampal volumetric changes in mice following brain infarctionBrait VH, Wright DK, Nategh M, Oman A, Syeda WT, Ermine CM, O'Brien KR, Werden E, Churilov L, Johnston LA, Thompson LH, Nithianantharajah J, Jackman KA, Brodtmann A.Sci Rep. 2021 May 13;11(1):10269. doi: 10.1038/s41598-021-88284-7.
33972525Deep learning-based predictive identification of neural stem cell differentiationZhu Y, Huang R, Wu Z, Song S, Cheng L, Zhu R.Nat Commun. 2021 May 10;12(1):2614. doi: 10.1038/s41467-021-22758-0.
33947043Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain InjuryKagan BJ, Ermine CM, Frausin S, Parish CL, Nithianantharajah J, Thompson LH.Int J Mol Sci. 2021 Apr 29;22(9):4740. doi: 10.3390/ijms22094740.
33879257Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injuryMallah K, Couch C, Alshareef M, Borucki D, Yang X, Alawieh A, Tomlinson S.Acta Neuropathol Commun. 2021 Apr 20;9(1):72. doi: 10.1186/s40478-021-01179-6.
33811249Metformin prevents stroke damage in non-diabetic female mice with chronic kidney diseaseGrissi M, Boudot C, Assem M, Candellier A, Lando M, Poirot-Leclercq S, Boullier A, Bennis Y, Lenglet G, Avondo C, Lalau JD, Choukroun G, Massy ZA, Kamel S, Chillon JM, Hénaut L.Sci Rep. 2021 Apr 2;11(1):7464. doi: 10.1038/s41598-021-86905-9.
33806692Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced ThrombosisShakova FM, Kirova YI, Silachev DN, Romanova GA, Morozov SG.Brain Sci. 2021 Mar 4;11(3):325. doi: 10.3390/brainsci11030325.
33781382All-trans retinoic acid induces synaptic plasticity in human cortical neuronsLenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A.Elife. 2021 Mar 30;10:e63026. doi: 10.7554/eLife.63026.
33742683Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptorAsuni GP, Speidell A, Mocchetti I.J Neurochem. 2021 Jul;158(2):169-181. doi: 10.1111/jnc.15355. Epub 2021 Apr 12.
33739978Optogenetic activation of spinal microglia triggers chronic pain in miceYi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ.PLoS Biol. 2021 Mar 19;19(3):e3001154. doi: 10.1371/journal.pbio.3001154. eCollection 2021 Mar.
33716930Levetiracetam and N-Cadherin Antibody Alleviate Brain Pathology Without Reducing Early Epilepsy Development After Focal Non-convulsive Status Epilepticus in RatsAvdic U, Ahl M, Andersson M, Ekdahl CT.Front Neurol. 2021 Feb 24;12:630154. doi: 10.3389/fneur.2021.630154. eCollection 2021.
33708771TBL1XR1 Ensures Balanced Neural Development Through NCOR Complex-Mediated Regulation of the MAPK PathwayMastrototaro G, Zaghi M, Massimino L, Moneta M, Mohammadi N, Banfi F, Bellini E, Indrigo M, Fagnocchi G, Bagliani A, Taverna S, Rohm M, Herzig S, Sessa A.Front Cell Dev Biol. 2021 Feb 23;9:641410. doi: 10.3389/fcell.2021.641410. eCollection 2021.
33659306Extracellular Vesicles Tracking and Quantification Using CT and Optical Imaging in RatsGuo S, Betzer O, Perets N, Landau S, Offen D, Popovtzer R, Levenberg S.Bio Protoc. 2020 Jun 5;10(11):e3635. doi: 10.21769/BioProtoc.3635. eCollection 2020 Jun 5.
33635633Acute Dose-Dependent Neuroprotective Effects of Poly(pro-17β-estradiol) in a Mouse Model of Spinal Contusion InjuryGottipati MK, Ellman SAT, Puhl DL, Guan Z, Popovich PG, Palermo EF, Gilbert RJ.ACS Chem Neurosci. 2021 Mar 17;12(6):959-965. doi: 10.1021/acschemneuro.0c00798. Epub 2021 Feb 26.
33624805Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db micePho H, Berger S, Freire C, Kim LJ, Shin MK, Streeter SR, Hosamane N, Cabassa ME, Anokye-Danso F, Dergacheva O, Amorim MR, Fleury-Curado T, Jun JC, Schwartz AR, Ahima RS, Mendelowitz D, Polotsky VY.Sleep. 2021 Jun 11;44(6):zsab046. doi: 10.1093/sleep/zsab046.
33535782Ultra-Early Cerebral Thrombosis Formation After Experimental Subarachnoid Hemorrhage Detected on T2* Magnetic Resonance ImagingWang Z, Chen J, Toyota Y, Keep RF, Xi G, Hua Y.Stroke. 2021 Mar;52(3):1033-1042. doi: 10.1161/STROKEAHA.120.032397. Epub 2021 Feb 4.
33514602Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule CellsParga Becerra A, Logsdon AF, Banks WA, Ransom CB.eNeuro. 2021 May 5;8(3):ENEURO.0055-20.2021. doi: 10.1523/ENEURO.0055-20.2021. Print 2021 May-Jun.
33479244Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson's diseaseFlores-Cuadrado A, Saiz-Sanchez D, Mohedano-Moriano A, Lamas-Cenjor E, Leon-Olmo V, Martinez-Marcos A, Ubeda-Bañon I.NPJ Parkinsons Dis. 2021 Jan 21;7(1):11. doi: 10.1038/s41531-020-00154-7.
33446516Complement Drives Synaptic Degeneration and Progressive Cognitive Decline in the Chronic Phase after Traumatic Brain InjuryAlawieh A, Chalhoub RM, Mallah K, Langley EF, York M, Broome H, Couch C, Adkins D, Tomlinson S.J Neurosci. 2021 Feb 24;41(8):1830-1843. doi: 10.1523/JNEUROSCI.1734-20.2020. Epub 2021 Jan 14.
33437626Neurotropin exerts neuroprotective effects after spinal cord injury by inhibiting apoptosis and modulating cytokinesYao X, Sun C, Fan B, Zhao C, Zhang Y, Duan H, Pang Y, Shen W, Li B, Wang X, Liu C, Zhou H, Kong X, Feng S.J Orthop Translat. 2020 Mar 23;26:74-83. doi: 10.1016/j.jot.2020.02.011. eCollection 2021 Jan.
33369735Abnormal cerebellar function and tremor in a mouse model for non-manifesting partially penetrant dystonia type 6van der Heijden ME, Kizek DJ, Perez R, Ruff EK, Ehrlich ME, Sillitoe RV.J Physiol. 2021 Apr;599(7):2037-2054. doi: 10.1113/JP280978. Epub 2021 Jan 9.
33328869Perampanel Add-on to Standard Radiochemotherapy in vivo Promotes Neuroprotection in a Rodent F98 Glioma ModelLange F, Hartung J, Liebelt C, Boisserée J, Resch T, Porath K, Hörnschemeyer J, Reichart G, Sellmann T, Neubert V, Kriesen S, Hildebrandt G, Schültke E, Köhling R, Kirschstein T.Front Neurosci. 2020 Nov 30;14:598266. doi: 10.3389/fnins.2020.598266. eCollection 2020.
33318402Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemiaGao Q, Leung A, Yang YH, Lau BW, Wang Q, Liao LY, Xie YJ, He CQ.Neural Regen Res. 2021 Jul;16(7):1252-1257. doi: 10.4103/1673-5374.301020.
33284107Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortexRuediger S, Scanziani M.Elife. 2020 Dec 7;9:e59247. doi: 10.7554/eLife.59247.
33269749Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injuryShao ZQ, Dou SS, Zhu JG, Wang HQ, Wang CM, Cheng BH, Bai B.Neural Regen Res. 2021 Jun;16(6):1044-1051. doi: 10.4103/1673-5374.300725.
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33051350Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial CellsFreria CM, Brennan FH, Sweet DR, Guan Z, Hall JC, Kigerl KA, Nemeth DP, Liu X, Lacroix S, Quan N, Popovich PG.J Neurosci. 2020 Nov 18;40(47):9103-9120. doi: 10.1523/JNEUROSCI.0131-20.2020. Epub 2020 Oct 13.
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32681050Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processingØstergaard FG, Himmelberg MM, Laursen B, Siebner HR, Wade AR, Christensen KV.Sci Rep. 2020 Jul 17;10(1):11869. doi: 10.1038/s41598-020-68808-3.
32675411Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type MiceVogels T, Vargová G, Brezováková V, Quint WH, Hromádka T.J Alzheimers Dis. 2020;77(2):551-568. doi: 10.3233/JAD-200047.
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32581664Bloodletting Puncture at Hand Twelve Jing-Well Points Improves Neurological Recovery by Ameliorating Acute Traumatic Brain Injury-Induced Coagulopathy in MiceLi B, Zhou X, Yi TL, Xu ZW, Peng DW, Guo Y, Guo YM, Cao YL, Zhu L, Zhang S, Cheng SX.Front Neurosci. 2020 Jun 5;14:403. doi: 10.3389/fnins.2020.00403. eCollection 2020.
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32531201Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy ChainMukherjee C, Kling T, Russo B, Miebach K, Kess E, Schifferer M, Pedro LD, Weikert U, Fard MK, Kannaiyan N, Rossner M, Aicher ML, Goebbels S, Nave KA, Krämer-Albers EM, Schneider A, Simons M.Cell Metab. 2020 Aug 4;32(2):259-272.e10. doi: 10.1016/j.cmet.2020.05.019. Epub 2020 Jun 11.
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32385776Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in MiceWang HL, Li JT, Wang H, Sun YX, Liu R, Wang XD, Su YA, Si TM.Neurosci Bull. 2020 Aug;36(8):860-874. doi: 10.1007/s12264-020-00499-2. Epub 2020 May 8.
32070183The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA(A) receptors in rat glaucoma modelsIshikawa M, Takaseki S, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.Autophagy. 2021 Mar;17(3):743-760. doi: 10.1080/15548627.2020.1731270. Epub 2020 Feb 27.
32024534Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in miceHolmkvist AD, Agorelius J, Forni M, Nilsson UJ, Linsmeier CE, Schouenborg J.J Nanobiotechnology. 2020 Feb 5;18(1):27. doi: 10.1186/s12951-020-0585-9.
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31983856Heterogeneity of Cells Population and Secretome Profile of Differentiated Cells from E17 Rat Neural Progenitor CellsBudiariati V, Rinendyaputri R, Noviantari A, Budiono D, Fahrudin M, Juliandi B, Boediono A.J Stem Cells Regen Med. 2019 Dec 24;15(2):35-44. doi: 10.46582/jsrm.1502008. eCollection 2019.
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31912469Repetitive Transcranial Magnetic Stimulation Alleviates Neurological Deficits After Cerebral Ischemia Through Interaction Between RACK1 and BDNF exon IV by the Phosphorylation-Dependent Factor MeCP2Li H, Shang J, Zhang C, Lu R, Chen J, Zhou X.Neurotherapeutics. 2020 Apr;17(2):651-663. doi: 10.1007/s13311-019-00771-y.
31888056CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on AgeLieschke S, Zechmeister B, Haupt M, Zheng X, Jin F, Hein K, Weber MS, Hermann DM, Bähr M, Kilic E, Doeppner TR.Cells. 2019 Dec 26;9(1):66. doi: 10.3390/cells9010066.
31824411Neuronal Membrane Disruption Occurs Late Following Diffuse Brain Trauma in Rats and Involves a Subpopulation of NeuN Negative Cortical NeuronsHernandez ML, Chatlos T, Gorse KM, Lafrenaye AD.Front Neurol. 2019 Nov 22;10:1238. doi: 10.3389/fneur.2019.01238. eCollection 2019.
31739796Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neuronsWinkler CW, Woods TA, Groveman BR, Carmody AB, Speranza EE, Martens CA, Best SM, Haigh CL, Peterson KE.J Neuroinflammation. 2019 Nov 18;16(1):229. doi: 10.1186/s12974-019-1614-1.
31654574Anxiety-like behavior in female mice changes by feeding, possible effect of guanylate cyclase CDugandzic A, Ratko M, Habek N.Eur J Neurosci. 2020 Jul;52(1):2781-2790. doi: 10.1111/ejn.14607. Epub 2019 Nov 28.
31616414CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain RegionsEasley-Neal C, Foreman O, Sharma N, Zarrin AA, Weimer RM.Front Immunol. 2019 Sep 20;10:2199. doi: 10.3389/fimmu.2019.02199. eCollection 2019.
31596896Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s diseaseMuñoz-Cabrera JM, Sandoval-Hernández AG, Niño A, Báez T, Bustos-Rangel A, Cardona-Gómez GP, Múnera A, Arboleda G.PLoS One. 2019 Oct 9;14(10):e0223578. doi: 10.1371/journal.pone.0223578. eCollection 2019.
31591949Chronic restraint stress exacerbates neurological deficits and disrupts the remodeling of the neurovascular unit in a mouse intracerebral hemorrhage modelGao C, Meng Y, Chen G, Chen W, Chen XS, Luo CL, Zhang MY, Wang ZF, Wang T, Tao LY.Stress. 2020 May;23(3):338-348. doi: 10.1080/10253890.2019.1678023. Epub 2019 Oct 18.
31543414Fetal Gene Therapy Using a Single Injection of Recombinant AAV9 Rescued SMA Phenotype in MiceRashnonejad A, Amini Chermahini G, Gündüz C, Onay H, Aykut A, Durmaz B, Baka M, Su Q, Gao G, Özkınay F.Mol Ther. 2019 Dec 4;27(12):2123-2133. doi: 10.1016/j.ymthe.2019.08.017. Epub 2019 Aug 31.
31512113Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER StressFu J, Peng L, Wang W, He H, Zeng S, Chen TC, Chen Y.Neurochem Res. 2019 Nov;44(11):2517-2526. doi: 10.1007/s11064-019-02870-w. Epub 2019 Sep 11.
31490123An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathwayAoki S, Smith JB, Li H, Yan X, Igarashi M, Coulon P, Wickens JR, Ruigrok TJ, Jin X.Elife. 2019 Sep 6;8:e49995. doi: 10.7554/eLife.49995.
31442405Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 TranscriptionSuh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE.Cell. 2019 Aug 22;178(5):1159-1175.e17. doi: 10.1016/j.cell.2019.07.043.
31435943Somato-dendritic morphology and axon origin site specify von Economo neurons as a subclass of modified pyramidal neurons in the human anterior cingulate cortexBanovac I, Sedmak D, Džaja D, Jalšovec D, Jovanov Milošević N, Rašin MR, Petanjek Z.J Anat. 2019 Sep;235(3):651-669. doi: 10.1111/joa.13068.
31408457Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivoMcAvoy KM, Rajamohamed Sait H, Marsh G, Peterson M, Reynolds TL, Gagnon J, Geisler S, Leach P, Roberts C, Cahir-McFarland E, Ransohoff RM, Crotti A.PLoS One. 2019 Aug 13;14(8):e0220125. doi: 10.1371/journal.pone.0220125. eCollection 2019.
31392787Bcl-2/Bax ratio increase does not prevent apoptosis of glia and granular neurons in patients with temporal lobe epilepsyToscano ECB, Vieira ÉLM, Portela ACDC, Reis JLJ, Caliari MV, Giannetti AV, Gonçalves AP, Siqueira JM, Suemoto CK, Leite REP, Nitrini R, Teixeira AL, Rachid MA.Neuropathology. 2019 Oct;39(5):348-357. doi: 10.1111/neup.12592. Epub 2019 Aug 7.
31374230Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling PathwayZhao H, Feng Y, Wei C, Li Y, Ma H, Wang X, Cui Z, Jin WN, Shi FD.Neuroscience. 2019 Sep 15;416:198-206. doi: 10.1016/j.neuroscience.2019.07.020. Epub 2019 Jul 30.
31364704Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X SyndromeLovelace JW, Rais M, Palacios AR, Shuai XS, Bishay S, Popa O, Pirbhoy PS, Binder DK, Nelson DL, Ethell IM, Razak KA.Cereb Cortex. 2020 Mar 14;30(3):969-988. doi: 10.1093/cercor/bhz141.
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31300647Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylationPark JS, Lee J, Jung ES, Kim MH, Kim IB, Son H, Kim S, Kim S, Park YM, Mook-Jung I, Yu SJ, Lee JH.Nat Commun. 2019 Jul 12;10(1):3090. doi: 10.1038/s41467-019-11000-7.
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31242827Eye Opener in StrokeNguyen H, Lee JY, Sanberg PR, Napoli E, Borlongan CV.Stroke. 2019 Aug;50(8):2197-2206. doi: 10.1161/STROKEAHA.119.025249. Epub 2019 Jun 27.
31234698Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficitsJung S, Choe S, Woo H, Jeong H, An HK, Moon H, Ryu HY, Yeo BK, Lee YW, Choi H, Mun JY, Sun W, Choe HK, Kim EK, Yu SW.Autophagy. 2020 Mar;16(3):512-530. doi: 10.1080/15548627.2019.1630222. Epub 2019 Jun 24.
31221481Correlation analysis of [(18)F]ROStrace using ex vivo autoradiography and dihydroethidium fluorescent imaging in lipopolysaccharide-treated animalsWeng CC, Carlin S, Hou C, Metz T, Li S, Lee H, Xu K, Makvandi M, Mach RH.Biochem Biophys Res Commun. 2019 Aug 20;516(2):397-401. doi: 10.1016/j.bbrc.2019.06.062. Epub 2019 Jun 17.
31191318Inhibition of TRIB3 Protects Against Neurotoxic Injury Induced by Kainic Acid in RatsZhang J, Han Y, Zhao Y, Li Q, Jin H, Qin J.Front Pharmacol. 2019 May 22;10:585. doi: 10.3389/fphar.2019.00585. eCollection 2019.
31152852Involvement of monocarboxylate transporters in the cross-tolerance between epilepsy and cerebral infarction: A promising choice towards new treatmentsGao C, Li Z, Bai J, Wang R, Gao L.Neurosci Lett. 2019 Aug 10;707:134305. doi: 10.1016/j.neulet.2019.134305. Epub 2019 May 29.
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31108173Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe diseaseDel Grosso A, Angella L, Tonazzini I, Moscardini A, Giordano N, Caleo M, Rocchiccioli S, Cecchini M.Neurobiol Dis. 2019 Sep;129:195-207. doi: 10.1016/j.nbd.2019.05.011. Epub 2019 May 17.
31080058Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing NeocortexShu P, Wu C, Ruan X, Liu W, Hou L, Fu H, Wang M, Liu C, Zeng Y, Chen P, Yin B, Yuan J, Qiang B, Peng X, Zhong W.Dev Cell. 2019 Jun 3;49(5):764-785.e4. doi: 10.1016/j.devcel.2019.04.017. Epub 2019 May 9.
31066147Postnatal nectin-3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult miceLiu R, Wang H, Wang HL, Sun YX, Su YA, Wang XD, Li JT, Si TM.Hippocampus. 2019 Nov;29(11):1063-1074. doi: 10.1002/hipo.23098. Epub 2019 May 8.
31015533Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney diseaseHénaut L, Grissi M, Brazier F, Assem M, Poirot-Leclercq S, Lenglet G, Boudot C, Avondo C, Boullier A, Choukroun G, Massy ZA, Kamel S, Chillon JM.Sci Rep. 2019 Apr 23;9(1):6432. doi: 10.1038/s41598-019-42933-0.
30883351Modulation of SPARC/Hevin Proteins in Alzheimer's Disease Brain InjuryStrunz M, Jarrell JT, Cohen DS, Rosin ER, Vanderburg CR, Huang X.J Alzheimers Dis. 2019;68(2):695-710. doi: 10.3233/JAD-181032.
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30721406Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligationSekiya H, Kowa H, Koga H, Takata M, Satake W, Futamura N, Funakawa I, Jinnai K, Takahashi M, Kondo T, Ueno Y, Kanagawa M, Kobayashi K, Toda T.Acta Neuropathol. 2019 Mar;137(3):455-466. doi: 10.1007/s00401-019-01961-w. Epub 2019 Feb 5.
30720927Isolation of Neural Stem Cells from Whole Brain Tissues of Adult MiceDeshpande K, Saatian B, Martirosian V, Lin M, Julian A, Neman J.Curr Protoc Stem Cell Biol. 2019 Jun;49(1):e80. doi: 10.1002/cpsc.80. Epub 2019 Feb 5.
30703361Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult miceDheer Y, Chitranshi N, Gupta V, Sharma S, Pushpitha K, Abbasi M, Mirzaei M, You Y, Graham SL, Gupta V.Exp Neurol. 2019 Apr;314:111-125. doi: 10.1016/j.expneurol.2019.01.015. Epub 2019 Jan 28.
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30618823Arcuate Nucleus Orexin-A Signaling Alleviates Cisplatin-Induced Nausea and Vomiting Through the Paraventricular Nucleus of the Hypothalamus in RatsGuo F, Gao S, Xu L, Sun X, Zhang N, Gong Y, Luan X.Front Physiol. 2018 Dec 17;9:1811. doi: 10.3389/fphys.2018.01811. eCollection 2018.
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23264599HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesisFranke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20.
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11 reviews for rabbit anti-NeuN polyclonal antibody 2615

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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample type:Mouse Tissue sections (DRG)
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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample type:Human Tissue sections (brain)
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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample type:Guinea pig Tissue sections (spinal cord)
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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample type:Rat Tissue sections (DRG)
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    Immunohistochemistry free floating
    Sample type:Mouse Tissue sections (Ileum)
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    Immunohistochemistry (Frozen sections)
    Sample type:Mouse Tissue sections (Brain)
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    Immunocytochemistry/ Immunofluorescence
    Sample type:Human Cell (iPSC-derived neurons)
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    Immunohistochemistry (Frozen sections)
    Sample type:Mouse Tissue sections (Brain (Embryonic day 14.5))
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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample type:Mouse Tissue sections (brain)
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    Immunohistochemistry (PFA perfusion fixed frozen sections)
    Sample type:Rat Tissue sections (Brain)
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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample type:Cynomolgus monkey Tissue sections (Cerebrum & Cerebellum)

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