Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | chicken |
isotype | IgY |
clonality | polyclonal |
concentration | 1 mg/mL |
applications | ICC/IF, IHC, WB |
reactivity | human, mouse, rat |
available sizes | 1 mg, 100 µg, 25 µg |
rabbit anti-GFAP polyclonal antibody 2539
$100.00 – $2,600.00
Antibody summary
- Rabbit polyclonal to GFAP
- Suitable for: WB, ICC/IF, IHC
- Reacts with: human, mouse, rat
- Isotype: IgG
- 100 µg
rabbit anti-GFAP polyclonal antibody 2539
target relevance |
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Glial Fibrillary Acidic Protein (GFAP) is a crucial cell marker widely employed in neuroscience and neurobiology research. It is an intermediate filament protein primarily found in astrocytes, a type of glial cell in the central nervous system. GFAP serves as a reliable marker for identifying and characterizing astrocytes in various experimental models and tissues. Immunohistochemistry and immunofluorescence techniques using antibodies targeting GFAP enable researchers to visualize and quantify astrocytic populations, gaining insights into their distribution, morphology, and function in the brain. Moreover, GFAP antibodies are instrumental in studying astrocyte reactivity, a phenomenon occurring in response to brain injury or neurodegenerative diseases. As astrocytes play critical roles in neural development, neurotransmitter regulation, and maintenance of the blood-brain barrier, GFAP has proven indispensable in advancing our understanding of glial biology and its contribution to neurological disorders. Click for more on: cell markers and GFAP |
Protein names Glial fibrillary acidic protein (GFAP) |
Gene names GFAP,GFAP |
Protein family Intermediate filament family |
Mass 49880Da |
Function GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
Subellular location Cytoplasm Note=Associated with intermediate filaments. |
Tissues Expressed in cells lacking fibronectin. |
Structure Interacts with SYNM. ; [Isoform 2]: Interacts with PSEN1 (via N-terminus). |
Post-translational modification Phosphorylated by PKN1. |
Involvement in disease Alexander disease (ALXDRD) [MIM:203450]: A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes. Note=The disease is caused by variants affecting the gene represented in this entry. |
Target Relevance information above includes information from UniProt accession: P14136 |
The UniProt Consortium |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.There are 1040 publications in our database for this antibody or clone. Here are the latest 5, for more click below.
pmid | title | authors | citation |
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36600259 | Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice | Bellut M, Bieber M, Kraft P, Weber ANR, Stoll G, Schuhmann MK. | J Neuroinflammation. 2023 Jan 4;20(1):4. doi: 10.1186/s12974-022-02674-w. |
36596518 | Specific Cellular Effects of Low Bortezomib Concentrations on Purified Cultures of Schwann Cells, Satellite Glial Cells, Macrophages, and Dorsal Root Ganglion Neurons | Zhou Z, Nagayasu K, Shirakawa H, Kaneko S. | Biol Pharm Bull. 2023;46(1):102-110. doi: 10.1248/bpb.b22-00668. |
36572898 | Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions | Xu J, Ji T, Li G, Zhang H, Zheng Y, Li M, Ma J, Li Y, Chi G. | J Neuroinflammation. 2022 Dec 26;19(1):314. doi: 10.1186/s12974-022-02678-6. |
36531208 | Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats | Liu Y, Liu R, Huang L, Zuo G, Dai J, Gao L, Shi H, Fang Y, Lu Q, Okada T, Wang Z, Hu X, Lenahan C, Tang J, Xiao J, Zhang JH. | Oxid Med Cell Longev. 2022 Dec 9;2022:7727616. doi: 10.1155/2022/7727616. eCollection 2022. |
36529767 | The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage | Sun Y, Liu E, Pei Y, Yao Q, Ma H, Mu Y, Wang Y, Zhang Y, Yang X, Wang X, Xue J, Zhai J, Carare RO, Qin L, Yan J. | Acta Neuropathol Commun. 2022 Dec 18;10(1):187. doi: 10.1186/s40478-022-01492-8. |
Protocols
relevant to this product |
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Western blot IHC ICC |
Documents
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Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. |
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