Immunohistochemistry (IHC) : Human prostate carcinoma stained anti-AMACR and anti-p63 antibodies using peroxidase-conjugate and DAB chromogen. Note cytoplasmic and luminal circumferential staining of carcinoma glands with AMACR and basal cell nuclear staining with p63.

rabbit anti-AMACR + p63 monoclonal antibody (13H4 + ZM70) 6018

Price range: $160.00 through $528.00

Antibody summary

Rabbit monoclonal to AMACR + p63
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG, IgG1a/k
Control: Prostate carcinoma
Visualization: Cytoplasmic and nuclear
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

available sizes

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SKU: 6018parent Categories: antibody, Zeta IHC antibodies Tags: AMACR, anatomy, p63, Urinary Pathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG, IgG1a/k
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-AMACR + p63 monoclonal antibody 13H4 + ZM70 6018

antibody
Database link: human Q9UHK6 human Q9H3D4
Tested applications IHC
Recommended dilutions Concentrated 1:50
Application Notes Positive control: Prostate carcinoma
Immunogen Human AMACR (P504S) and p63 polypeptides
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Homo sapiens AMACR Alpha-methylacyl-CoA racemase
Protein names Alpha-methylacyl-CoA racemase
Alternative names 2-methylacyl-CoA racemase
Gene names AMACR
Protein family Belongs to the CoA-transferase III family
Function Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:10655068, PubMed:11060359, PubMed:7649182). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:10655068, PubMed:11060359, PubMed:7649182)
Catalytic activity a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA (2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA
Subcellular location Peroxisome, Mitochondrion
Structure Monomer
Involvement in disease Alpha-methylacyl-CoA racemase deficiency A rare autosomal recessive peroxisomal disorder characterized by elevated plasma concentrations of pristanic acid C27-bile-acid intermediates, and adult onset of variable neurodegenerative symptoms affecting the central and peripheral nervous systems. Features may include seizures, visual failure, sensorimotor neuropathy, spasticity, migraine, and white matter hyperintensities on brain imaging. Congenital bile acid synthesis defect 4 A disorder characterized by the presence of trihydroxycoprostanic acid in the bile and absence of cholic acid. Patients manifest neonatal jaundice, intrahepatic cholestasis and bile duct deficiency.
Keywords Acetylation, Alternative splicing, Disease variant, Intrahepatic cholestasis, Isomerase, Mitochondrion, Peroxisome, Proteomics identification, Reference proteome
Sequence MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQP RGAAVLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLA GHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQF YELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTF EEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEHTEEILEEFGFS REEIYQLNSDKIIESNKVKASL
UniProt accession: Q9UHK6

Data

Human prostate carcinoma stained anti-AMACR and anti-p63 antibodies using peroxidase-conjugate and DAB chromogen. Note cytoplasmic and luminal circumferential staining of carcinoma glands with AMACR and basal cell nuclear staining with p63.

FAQ & Publications

Frequently Asked Questions

What species is the rabbit anti-AMACR + p63 monoclonal antibody (13H4 + ZM70) 6018 reactive with?

This antibody is reactive with human tissues, making it suitable for studies involving human samples.

How should the rabbit anti-AMACR + p63 monoclonal antibody be stored to maintain its stability?

For short-term storage, keep the antibody at 2-8°C. For long-term preservation, store it at -20°C and avoid repeated freeze/thaw cycles to maintain antibody integrity.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.