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Epstein-Barr Virus-VCA IgM ELISA kit-SERION classic ESR1361M

$392.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Epstein-Barr Virus (EBV)-VCA IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR1361M Category: Virion/Serion kits Tags: ELISA, Epstein-Barr Virus, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Epstein-Barr Virus/VCA reactive IgM
species reactivity	Epstein-Barr Virus (EBV) (mononucleosis, mono, glandular fever)
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Epstein-Barr Virus-VCA IgM ELISA Kit ESR1361M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

Associated products
Epstein-Barr Virus (EBV) Capsid Antigen P18, alternative buffer Control Antigen (BA1361R01)
Epstein Barr Virus (EBV) Capsid Antigen (BA1361VSR21)
Epstein Barr Virus (EBV) Capsid Antigen (BA1361VSR22)
Epstein Barr Virus (EBV) Nuclear Antigen (BA1362VS)
Epstein Barr Virus (EBV) Early Antigen (BA1363P54VS)
Epstein Barr Virus (EBV) Early Antigen (BA1363VSR6)
Epstein-Barr Virus VCA IgG Control Serum (BC1361G)
Epstein-Barr Virus VCA IgM Control Serum (BC1361M)
Epstein-Barr Virus EBNA-1 IgG Control Serum (BC1362G)
Epstein-Barr Virus EA IgG Control Serum (BC1363G)
Epstein-Barr Virus/VCA IgM ELISA Kit (ESR1361M)
Epstein-Barr Virus EA IgG ELISA Kit (ESR1363G)

target relevance

human antibody anti-Epstein-Barr Virus

Epstein-Barr Virus

Description
Virus that causes infectious mononucleosis and is associated with several human cancers

Structure
Epstein-Barr virus (EBV), also known as Human herpesvirus 4 (HHV-4), is an enveloped, double-stranded DNA virus belonging to the genus Lymphocryptovirus within the family Herpesviridae. The virus possesses an icosahedral nucleocapsid surrounded by a protein tegument and a lipid envelope containing multiple viral glycoproteins involved in host cell attachment and entry. EBV primarily infects B lymphocytes and epithelial cells and establishes lifelong latent infection following primary exposure. More than 90% of the world's adult population carries the virus. During latency, EBV persists within memory B cells and can periodically reactivate, resulting in viral shedding and transmission. EBV is associated with several malignancies, including Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, gastric carcinoma, and post-transplant lymphoproliferative disorders.

Diagnosis
The diagnosis of Epstein-Barr virus infection is performed through serological, molecular, and hematological methods. Detection of heterophile antibodies using the Monospot test is commonly used for the diagnosis of infectious mononucleosis, although sensitivity may vary depending on age and stage of infection. EBV-specific serological assays measuring antibodies against viral capsid antigen (VCA), early antigen (EA), and Epstein-Barr nuclear antigen (EBNA) provide valuable information regarding acute, past, or reactivated infection. Molecular methods such as quantitative polymerase chain reaction (PCR) are used to detect and monitor viral DNA, particularly in immunocompromised patients and individuals at risk of EBV-associated malignancies. Hematological findings often include atypical lymphocytosis during acute infection.

Symptoms
Epstein-Barr virus is primarily transmitted through saliva and is often referred to as the cause of the 'kissing disease.' Following an incubation period of approximately four to six weeks, primary infection may result in infectious mononucleosis characterized by fever, fatigue, sore throat, enlarged lymph nodes, headache, and splenomegaly. Many infections in childhood are asymptomatic or cause only mild illness. Fatigue may persist for weeks or months following acute infection. In immunocompromised individuals, EBV can cause severe lymphoproliferative disease and contribute to the development of certain cancers. Although most infections resolve without complications, rare severe manifestations include hepatitis, neurological complications, hemolytic anemia, and splenic rupture.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Epstein-Barr Virus-VCA IgM ELISA Kit ESR1361M?

The Epstein-Barr Virus-VCA IgM ELISA Kit ESR1361M is suitable for use with serum, plasma, and whole blood samples.

Why is RF-Absorbent Z200 recommended for use with this IgM ELISA kit?

RF-Absorbent Z200 is recommended to pretreat samples in order to remove IgM rheumatoid factors from serum and plasma. This helps to eliminate potential false negative results and improves signal specificity during pathogen-specific IgM detection.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR1361M protocol

Documents

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EP0240	Safety Data Sheet	QC certificate
EQ0205	Safety Data Sheet	QC certificate

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Epstein-Barr Virus-VCA IgM ELISA kit-SERION classic ESR1361M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

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Reviews

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