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Dengue Virus superior IgM ELISA kit-SERION <i>classic</i> ESR1141M - Image 2

Dengue Virus superior IgM ELISA kit-SERION <i>classic</i> ESR1141M - Image 3

Dengue Virus superior IgM ELISA kit-SERION classic ESR1141M

$398.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Dengue Virus (DENV) superior IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR1141M Category: Virion/Serion kits Tags: Dengue Virus, ELISA, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Dengue Virus superior reactive IgM
species reactivity	Dengue Virus
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Dengue Virus superior IgM ELISA Kit ESR1141M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2 - 8°C until expiration on packaging.

Associated products
Dengue Virus superior Human IgM Assay Control (BC1141M)
Dengue Virus Human IgM Assay Control (BC114M)
Dengue Virus Human IgG Assay Control (BC114G)
Dengue Virus superior IgM ELISA Kit (ESR1141M)
Dengue Virus IgG ELISA Kit (ESR114G)
Dengue Virus IgM ELISA Kit (ESR114M)

target relevance

human antibody anti-Dengue Virus

Dengue Virus

Description
Virus that causes dengue fever and severe dengue

Structure
Dengue virus (DENV) is an enveloped, positive-sense, single-stranded RNA virus belonging to the genus Flavivirus within the family Flaviviridae. Four antigenically distinct serotypes, designated DENV-1, DENV-2, DENV-3, and DENV-4, are capable of causing human disease. The virus is transmitted primarily through the bites of infected Aedes mosquitoes, particularly Aedes aegypti and Aedes albopictus. Following transmission, dengue virus infects dendritic cells, monocytes, macrophages, and other susceptible cells before disseminating throughout the body. Infection with one serotype typically provides long-term immunity against that serotype but only partial and temporary protection against the others. Secondary infection with a different serotype may increase the risk of severe disease through antibody-dependent enhancement (ADE). Dengue virus is one of the most important mosquito-borne viral pathogens worldwide, particularly in tropical and subtropical regions.

Diagnosis
The diagnosis of dengue virus infection is performed through molecular, antigen detection, and serological methods. During the acute phase of illness, reverse transcription polymerase chain reaction (RT-PCR) and detection of the nonstructural protein 1 (NS1) antigen provide sensitive and specific identification of infection. Serological assays, including ELISA-based tests for dengue-specific IgM and IgG antibodies, are commonly used after the acute viremic phase. Interpretation of serological results may be complicated by cross-reactivity with other flaviviruses such as Zika virus, West Nile virus, and Yellow fever virus. Laboratory findings often include leukopenia, thrombocytopenia, elevated liver enzymes, and evidence of increased vascular permeability. Early laboratory confirmation is important for patient monitoring and management.

Symptoms
Dengue virus infection typically develops following an incubation period of approximately four to ten days after the bite of an infected mosquito. Classic dengue fever is characterized by sudden onset of high fever, severe headache, retro-orbital pain, muscle aches, joint pain, fatigue, nausea, vomiting, and a maculopapular rash. The intense muscle and joint pain has led to dengue being nicknamed 'breakbone fever.' Most infections are self-limiting and resolve within one to two weeks. However, a subset of patients develops severe dengue, formerly known as dengue hemorrhagic fever or dengue shock syndrome, characterized by plasma leakage, severe bleeding, thrombocytopenia, organ dysfunction, and circulatory shock. Severe dengue can be life-threatening and requires prompt medical management, particularly in children, elderly individuals, and patients experiencing secondary infection with a different dengue serotype.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Dengue Virus superior IgM ELISA Kit ESR1141M?

The kit is compatible with serum, plasma, and whole blood samples for the detection of Dengue Virus specific IgM antibodies.

How should the Dengue Virus superior IgM ELISA Kit ESR1141M be stored to maintain stability?

Store the kit at 2 to 8°C until the expiration date indicated on the packaging to ensure reagent stability and performance.

Why is RF-Absorbent Z200 recommended when using this IgM ELISA kit?

RF-Absorbent Z200 is recommended for pretreatment of samples to remove rheumatoid factors, which can otherwise interfere with IgM detection and cause false negative results, thereby improving signal specificity.

What is the assay type and principle of the Dengue Virus superior IgM ELISA Kit ESR1141M?

The kit uses an indirect and quantitative ELISA assay format designed for the detection of Dengue Virus specific IgM antibodies.

Publications

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Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

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Dengue Virus superior IgM ELISA kit-SERION classic ESR1141M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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