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Dengue Virus IgM ELISA Kit ESR114M

$334.00

Summary

  • Virion/Serion Diagnostic Kit for research use (RUO)
  • Dengue Virus IgM ELISA Kit
  • Suitable for IgM detection
  • Ready-to-use
  • 96 tests
Weight1 lbs
Dimensions9 × 5 × 2 in
target

Dengue Virus reactive IgM

species reactivity

Dengue Virus

applications

ELISA

assay type

Indirect & quantitative

available sizes

96 tests

Available product – Dengue Virus IgM ELISA Kit ESR114M

kit
Assay type
Indirect ELISA
Research area
Infectious Disease
Sample type
Serum, plasma, whole blood
Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.
Components
Break apart microtiter test strips each with antigen coated single wells8 x 12 (96 Total)
Standard serum (ready-to-use)2 x 2 mL
Negative control serum (ready-to-use)2 mL
Anti-human-IgM-conjugate (ready-to-use)13 mL
Washing solution concentrate (sufficient for 1000ml)33.3 mL
Dilution buffer2 x 50 mL
Stopping solution15 mL
Substrate (ready-to-use)13 mL
Quality control certificate with standard curve and evaluation table1
Storage
Store at 2-8°C.
Associated products
Dengue Virus superior Human IgM Assay Control (BC1141M)
Dengue Virus Human IgM Assay Control (BC114M)
Dengue Virus Human IgG Assay Control (BC114G)
Dengue Virus superior IgM ELISA Kit (ESR1141M)
Dengue Virus IgG ELISA Kit (ESR114G)
Dengue Virus IgM ELISA Kit (ESR114M)
target relevance
Organism
Dengue Virus
Structure and strains
Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. Nevertheless, scientists' understanding of dengue virus may be simplistic as, rather than distinct antigenic groups, a continuum appears to exist. This same study identified 47 strains of dengue virus. Additionally, coinfection with and lack of rapid tests for Zika virus and chikungunya complicate matters in real-world infections.

Dengue virus has increased dramatically within the last 20 years, becoming one of the worst mosquito-borne human pathogens that tropical countries have to deal with. Current estimates indicate that as many as 390 million infections occur each year, and many dengue infections are increasingly understood to be asymptomatic or subclinical.
Disease
Dengue Virus is transferred to humans by mosquitos. Approximately 3.9 billion individuals reside in Dengue endemic risk areas. According to the World Health Organization (WHO), up to 390 million cases of Dengue Fever occur worldwide each year. The single-stranded RNA Dengue Virus is a member of the family Flaviviridae. Dengue Viruses can be classified into four different serovars namely DEN-1, DEN-2, DEN-3 and DEN-4.

The incubation period for Dengue Fever is four to six days. The classical course of an infection is characterized by fever, headache, myalgia, arthralgia and a typical rash. All four serotypes induce a serotype-specific not crossprotective long-term immunity. During secondary infections, additional symptoms such as bleedings and shock are frequently observed. It is assumed that Dengue Hemorrhagic Fever (DHF) may result from follow up infections caused by heterologous Dengue Virus serotypes via antibody dependent enhancement. Overall, about 2 % - 5 % of the reported DHF cases are fatal. If a clinical
Detection and diagnosis
Between day 1 to 5 post onset of symptoms NS1 antigen detection as well as PCR are the most reliable methods to identify a Dengue Virus infection. Subsequently, serology is the method of choice for laboratory diagnostics. According to the Pan American Health Organization (PAHO) guidelines 80 % of all Dengue fever cases develop IgM antibodies by day 5 of illness, and 93-99 % have detectable IgM antibodies by day 6 post onset of symptoms, which may then remain detectable for more than 90 days. IgG antibodies are detectable at the end of the first week of illness and persist several months or even lifelong.

Data

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
ESR114M protocol

Documents

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