| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | Coxiella burnetii reactive IgM Phase II |
| species reactivity | Coxiella burnetii (Q fever) |
| applications | ELISA |
| assay type | Indirect & quantitative |
| available sizes | 96 tests |
Coxiella burnetii IgM Phase II ELISA kit-SERION classic ESR1312M
$355.00
RF-Absorbent Z200 for use with IgM ELISA kits
Did you know that RF Absorbent Z200 is recommended for the removal of IgM rheumatoid factors from serum and plasma samples prior to the detection of pathogen-specific IgM? Consider adding it to your cart for improved signal specificity. For more details, please refer to the IgM ELISA kit protocol.
- Virion/Serion Diagnostic Kit for research use (RUO)
- Coxiella burnetii IgM Phase II ELISA Kit
- Suitable for IgM detection
- Ready-to-use
- 96 tests
Coxiella burnetii IgM Phase II ELISA Kit ESR1312M
| kit | ||||||||||||||||||
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| Assay type Indirect ELISA | ||||||||||||||||||
| Research area Infectious Disease | ||||||||||||||||||
| Sample type Serum, plasma, whole blood | ||||||||||||||||||
| Notes Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results. | ||||||||||||||||||
Components
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| Storage Store at 2-8°C. | ||||||||||||||||||
| Associated products Coxiella burnetii Phase 2 IgG Control Serum (BC1312G) Coxiella burnetii Phase 2 IgM Control Serum (BC1312M) Coxiella burnetii IgA Phase I ELISA Kit (ESR1311A) Coxiella burnetii IgG Phase I ELISA Kit (ESR1311G) Coxiella burnetii IgG Phase II ELISA Kit (ESR1312G) Coxiella burnetii IgM Phase II ELISA Kit (ESR1312M) |
| target relevance |
|---|
| Organism Coxiella burnetii |
| Protein names Coxiella burnetii |
| Structure and strains Coxiella burnetii is an obligate intracellular bacterial pathogen, and is the causative agent of Q fever. The genus Coxiella is morphologically similar to Rickettsia, but with a variety of genetic and physiological differences. C. burnetii is a small Gram-negative, coccobacillary bacterium that is highly resistant to environmental stresses such as high temperature, osmotic pressure, and ultraviolet light. These characteristics are attributed to a small cell variant form of the organism that is part of a biphasic developmental cycle, including a more metabolically and replicatively active large cell variant form. It can survive standard disinfectants, and is resistant to many other environmental changes like those presented in the phagolysosome. |
| Detection and diagnosis The diagnosis of Q fever is performed by the demonstration of specific antibodies directed against Coxiella burnetii. Due to variations in the lipopolysaccharide (LPS) structure on the surface of the pathogen, as the disease enters the chronic state, a serological differentiation of acute from chronic infections is possible. Due to the high sensitivity and specificity, the use of ELISA immunoassays is recommended by the World Health Organization (WHO). Following the regular course of an acute primary infection, specific IgM and IgG antibodies directed against the immunogenic phase 2 antigens can be demonstrated. IgG antibodies directed against phase 2 antigens often persist over several years. In the lead-up to a chronic infection, IgG and IgA antibodies directed against the phase 1 antigens appear, which are of diagnostic value particularly for the diagnosis of Q fever endocarditis |
Data
FAQ & Publications
Frequently Asked Questions
What is the primary application of the Coxiella burnetii IgM Phase II ELISA Kit ESR1312M?
The Coxiella burnetii IgM Phase II ELISA Kit ESR1312M is designed for indirect and quantitative detection of IgM antibodies specific to Coxiella burnetii Phase II antigens, primarily for research use in infectious disease studies.
Which sample types are compatible with this ELISA kit?
This ELISA kit is compatible with serum, plasma, and whole blood samples for the detection of Coxiella burnetii IgM Phase II antibodies.
What storage conditions are recommended for maintaining the Coxiella burnetii IgM Phase II ELISA Kit?
The kit components should be stored at 2-8°C to ensure stability and optimal performance.
Is there a recommended pretreatment step for samples used with this IgM ELISA kit?
Yes, pretreatment of samples with RF-Absorbent (Z200) is recommended to remove rheumatoid factors from serum and plasma samples, which helps to prevent false negative results and improves signal specificity.
What components are included in the Coxiella burnetii IgM Phase II ELISA Kit ESR1312M?
The kit includes 8 strips of 12 antigen-coated wells (96 total), ready-to-use standard serum, negative control serum, anti-human-IgM conjugate, washing solution concentrate, dilution buffer, stopping solution, substrate, and a quality control certificate with standard curve and evaluation table.
Publications
| pmid | title | authors | citation |
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| We haven't added any publications to our database yet. | |||
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
Protocols
| relevant to this product |
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| ESR1312M protocol |
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