Immunohistochemistry (IHC) : Human gastric mucosa stained with anti-MUC-6 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of glandular cells.

rabbit anti-MUC-6 monoclonal antibody (ZR437) 6272

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to MUC-6
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Stomach
Visualization: Cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6272parent Category: antibody Tags: anatomy, monoclonal, MUC-6, Soft Tissue Pathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-MUC-6 monoclonal antibody ZR437 6272

antibody
Database link: human Q6W4X9
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Applicaiton Notes Positive control: Stomach
Immunogen Recombinant fragment covering tandem repeats of human MUC-6 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Mucin-6 (MUC-6) (Gastric mucin-6)
Mass 257051Da
Function May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Subellular location Secreted.
Tissues Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Structure Multimer; disulfide-linked.
Post-translational modification PTM: O-glycosylated.
Domain DOMAIN 43..214; /note="VWFD 1"; /evidence="ECO:0000255\|PROSITE-ProRule:PRU00580"; DOMAIN 302..357; /
Target Relevance information above includes information from UniProt accession: Q6W4X9
The UniProt Consortium

Data

Human gastric mucosa stained with anti-MUC-6 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of glandular cells.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.