Immunohistochemistry (IHC) : Human gastric mucosa stained with anti-MUC-6 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of glandular cells.

mouse anti-MUC-6 monoclonal antibody (ZM89) 6271

$160.00 – $528.00

Antibody summary

Mouse monoclonal to MUC-6
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG1
Control: Stomach
Visualization: Cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6271parent Category: antibody Tags: anatomy, MUC-6, Soft Tissue Pathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG1
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

mouse anti-MUC-6 monoclonal antibody ZM89 6271

antibody
Database link: human Q6W4X9
Tested applications IHC
Recommended dilutions As directed
Immunogen M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(ab-) patient
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG1
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control Mouse monoclonal IgG1 - Isotype Control

target relevance
Protein names Mucin-6 (MUC-6) (Gastric mucin-6)
Mass 257051Da
Function May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. .
Subellular location Secreted.
Tissues Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. .
Structure Multimer; disulfide-linked. .
Post-translational modification PTM: O-glycosylated. .
Domain DOMAIN 43..214; /note="VWFD 1"; /evidence="ECO:0000255\|PROSITE-ProRule:PRU00580"; DOMAIN 302..357; /
Target Relevance information above includes information from UniProt accession: Q6W4X9
The UniProt Consortium

Data

Human gastric mucosa stained with anti-MUC-6 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of glandular cells.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.