Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human pancreatic ductal carcinoma stained with anti-S100P antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells

rabbit anti-S100P monoclonal antibody (ZR115) 6435

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to S100P
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Colon cancer
Visualization: Membranous
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6435parent Category: antibody Tags: anatomy, General & Epithelial Markers, S100P

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-S100P monoclonal antibody ZR115 6435

antibody
Database link: human P25815
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Applicaiton Notes Colon cancer
Immunogen Recombinant fragment (around aa3-92) of human S100B protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)
Protein family S-100 family
Mass 10400Da
Function May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
Subellular location Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
Tissues Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.
Structure Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.; (Microbial infection) Interacts with P.falciparum (strains 3D7 and FVO) MSP1 subunit p33; the interaction blocks S100P inflammatory and chemotactic activities.
Domain DOMAIN 12..47; /note="EF-hand 1"; /evidence="ECO:0000305"; DOMAIN 49..84; /note="EF-hand 2"; /eviden
Target Relevance information above includes information from UniProt accession: P25815
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human pancreatic ductal carcinoma stained with anti-S100P antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.