Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human neuroblastoma stained with anti-PHOX2B antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells

rabbit anti-PHOX2B monoclonal antibody (ZR292) 6334

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to PHOX2B
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Neuroblastoma
Visualization: Nuclear
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6334parent Category: antibody Tags: anatomy, monoclonal, Neuropathology/Endocrine, PHOX2B

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-PHOX2B monoclonal antibody ZR292 6334

antibody
Database link: human O14601
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Applicaiton Notes Positive control: Neuroblastoma
Immunogen Recombinant fragment of human PHOX2B protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B)
Gene names PHOX2B,PHOX2B PMX2B
Protein family Paired homeobox family
Mass 31621Da
Tissues TISSUE SPECIFICITY: Expressed in neuroblastoma, brain and adrenal gland.
Structure SUBUNIT: Interacts with TRIM11. {ECO:0000250}.
Involvement in disease DISEASE: Central hypoventilation syndrome, congenital, 1 (CCHS1) [MIM:209880]: An autosomal dominant form of congenital central hypoventilation syndrome, a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. {ECO:0000269\|PubMed:12640453, ECO:0000269\|PubMed:14566559, ECO:0000269\|PubMed:15657873}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Neuroblastoma 2 (NBLST2) [MIM:613013]: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. {ECO:0000305\|PubMed:15024693}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: Q99453
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human neuroblastoma stained with anti-PHOX2B antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.