Immunohistochemistry (IHC) : Human neuroendocrine carcinoma stained with anti-CD56 antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of tumor cells.

rabbit anti-CD56 monoclonal antibody (ZR421) 6103

Price range: $160.00 through $528.00

Antibody summary

Rabbit monoclonal to CD56
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Neuroblastoma, neuroendocrine carcinoma
Visualization: Cell membrane
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

available sizes

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SKU: 6103parent Category: antibody Tags: anatomy, CD56, monoclonal, Neuropathology/Endocrine

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-CD56 monoclonal antibody ZR421 6103

antibody
Database link: human P13591
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Application Notes Positive control: Neuroblastoma, neuroendocrine carcinoma
Immunogen Recombinant fragment (around aa600-800) of human NCAM1 (CD56) protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)
Gene names NCAM1,NCAM1 NCAM
Mass 94574Da
Function FUNCTION: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; FUNCTION: (Microbial infection) Acts as a receptor for rabies virus. {ECO:0000269\|PubMed:9696812}.; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus. {ECO:0000269\|PubMed:32753727}.
Subellular location SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.
Structure SUBUNIT: (Microbial infection) Interacts with rabies virus glycoprotein. {ECO:0000269\|PubMed:9696812}.; SUBUNIT: (Microbial infection) Interacts with Zika virus envelope protein E. {ECO:0000269\|PubMed:32753727}.; SUBUNIT: Interacts with MDK. Found in a complex with SLC39A6, SLC39A10 and with NCAM1; this complex controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-tomesenchymal transition. Interacts with synaptic plasticity regulator PANTS. {ECO:0000250\|UniProtKB:P13595}.
Post-translational modification PTM: Polysialylated at Asn-459 and Asn-488 by ST8SIA2 and ST8SIA4 (PubMed:28810663). Polysialylation modulates cell interactions by confering both attractive and repulsive properties that are highly regulated by ST8SIA2 and ST8SIA4 (PubMed:28810663). Polysialylation is formed on a-2,3-linked sialic acid of core glycans (PubMed:9774483). {ECO:0000269\|PubMed:28810663, ECO:0000269\|PubMed:9774483}.
Target Relevance information above includes information from UniProt accession: P13591
The UniProt Consortium

Data

Human neuroendocrine carcinoma stained with anti-CD56 antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of tumor cells.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.