Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | mouse |
isotype | IgG2b |
clonality | monoclonal |
concentration | concentrate, predilute |
applications | IHC |
reactivity | human |
available size | 0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted |
mouse anti-Mesothelin monoclonal antibody (ZM25) 6253
$160.00 – $528.00
Antibody summary
- Mouse monoclonal to Mesothelin
- Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
- Reacts with: Human
- Isotype:IgG2b
- Control: Mesothelioma
- Visualization: Cytoplasmic
- 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
mouse anti-Mesothelin monoclonal antibody ZM25 6253
target relevance |
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Protein names Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form] |
Gene names MSLN,MSLN MPF |
Protein family Mesothelin family |
Mass 68986Da |
Function FUNCTION: Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. |
Subellular location SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted. |
Tissues TISSUE SPECIFICITY: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269|PubMed:16857795, ECO:0000269|PubMed:7665620}. |
Structure SUBUNIT: Interacts with MUC16. {ECO:0000269|PubMed:14676194, ECO:0000269|PubMed:22787150}. |
Post-translational modification PTM: Both MPF and the cleaved form of mesothelin are N-glycosylated. {ECO:0000269|PubMed:16857795, ECO:0000269|PubMed:8288629, ECO:0000269|PubMed:8552591}.; PTM: Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. {ECO:0000269|PubMed:8552591}. |
Involvement in disease DISEASE: Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269|PubMed:15897581}. |
Target Relevance information above includes information from UniProt accession: Q13421 |
The UniProt Consortium |
Data
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Human mesothelioma stained with anti-Mesothelin antibody using peroxidase-conjugate and DAB chromogen. Note membranous staining of tumor cells. |
Publications
Publications
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Protocols
relevant to this product |
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IHC |
Documents
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