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Herpes simplex Virus 1 and 2 IgM ELISA kit-SERION classic ESR105M

$402.00

Summary

Virion/Serion Diagnostic Kit for research use (RUO)
Herpes Simplex Virus (HSV) 1 and 2 IgM ELISA Kit
Suitable for IgM detection
Ready-to-use
96 tests

SKU: ESR105M Category: Virion/Serion kits Tags: ELISA, Herpes simplex Virus, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Herpes simplex Virus 1 and 2 reactive IgM
species reactivity	Herpes Simplex Virus
applications	ELISA
assay type	Indirect & quantitative
available sizes	96 tests

Herpes simplex Virus 1 and 2 IgM ELISA Kit ESR105M

Assay type
Indirect ELISA

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.

Components

Break apart microtiter test strips each with antigen coated single wells	8 x 12 (96 Total)
Standard serum (ready-to-use)	2 x 2 mL
Negative control serum (ready-to-use)	2 mL
Anti-human-IgM-conjugate (ready-to-use)	13 mL
Washing solution concentrate (sufficient for 1000ml)	33.3 mL
Dilution buffer	2 x 50 mL
Stopping solution	15 mL
Substrate (ready-to-use)	13 mL
Quality control certificate with standard curve and evaluation table	1

Storage
Store at 2-8°C.

Associated products
Herpes Simplex Virus 1+2 IgA Control Serum (BC105A)
Herpes Simplex Virus 1+2 IgG Control Serum (BC105G)
Herpes Simplex Virus 1+2 IgM Control Serum (BC105M)
Herpes simplex Virus 1 and 2 IgA ELISA Kit (ESR105A)
Herpes simplex Virus 1 and 2 IgG ELISA Kit (ESR105G)
Herpes simplex Virus 1 and 2 IgM ELISA Kit (ESR105M)

target relevance

human antibody anti-Herpes Simplex Virus (HSV)

Herpes Simplex Virus (HSV)

Description
Virus that causes oral herpes, genital herpes, and other mucocutaneous infections

Structure
Herpes simplex viruses (HSV) are enveloped, double-stranded DNA viruses belonging to the genus Simplexvirus within the family Herpesviridae. Two closely related species, Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), are responsible for the majority of human infections. The viral genome is enclosed within an icosahedral capsid surrounded by a protein tegument and a lipid envelope containing glycoproteins that mediate attachment and entry into host cells. Following primary infection, HSV establishes lifelong latency within sensory neurons, particularly in the trigeminal and sacral ganglia. Periodic reactivation of latent virus results in recurrent infections and viral shedding, often in the absence of symptoms. HSV infections are widespread globally and represent some of the most common viral infections of humans.

Diagnosis
The diagnosis of herpes simplex virus infection is performed through clinical evaluation and laboratory testing. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive and specific and are considered the preferred diagnostic approach for detecting HSV DNA in lesion swabs, cerebrospinal fluid, and other clinical specimens. Viral culture may also be used, particularly for active lesions, although it is generally less sensitive than PCR. Direct fluorescent antibody testing and antigen detection assays may provide rapid identification in selected settings. Serological assays, including ELISA-based tests, can detect HSV-specific antibodies and help distinguish previous exposure to HSV-1 and HSV-2. Laboratory confirmation is particularly important in cases of neonatal herpes, encephalitis, and atypical presentations.

Symptoms
Herpes simplex virus infections produce a wide range of clinical manifestations depending on the site of infection and immune status of the host. Primary infection may be asymptomatic or may present with painful vesicular lesions involving the oral cavity, lips, genital region, skin, or eyes. HSV-1 most commonly causes oral herpes characterized by fever, gingivostomatitis, and recurrent cold sores, whereas HSV-2 is more frequently associated with genital herpes causing painful ulcers, itching, dysuria, and regional lymphadenopathy. Recurrent episodes are typically milder than primary infections due to partial immune control. In immunocompromised individuals and neonates, HSV can cause severe disseminated disease. Rare but serious complications include herpes encephalitis, keratitis leading to vision loss, meningitis, and neonatal herpes, which may be life-threatening if untreated.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Herpes simplex Virus 1 and 2 IgM ELISA Kit ESR105M?

The kit is suitable for testing serum, plasma, and whole blood samples for the detection of Herpes simplex Virus 1 and 2 reactive IgM antibodies.

How should the Herpes simplex Virus 1 and 2 IgM ELISA Kit ESR105M be stored to maintain its stability?

The kit components should be stored at 2-8°C to ensure proper stability and performance.

Why is pretreatment of samples with RF-Absorbent Z200 recommended when using this IgM ELISA kit?

Pretreatment with RF-Absorbent Z200 is recommended to remove IgM rheumatoid factors from serum and plasma samples, which helps eliminate potential false negative results and improves signal specificity in the detection of pathogen-specific IgM.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
ESR105M protocol

Documents

#
EP0273	Safety Data Sheet	QC certificate
ER0045	Safety Data Sheet	QC certificate

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Herpes simplex Virus 1 and 2 IgM ELISA kit-SERION classic ESR105M

RF-Absorbent Z200 for use with IgM ELISA kits

Data

FAQ & Publications

Protocols

Documents

Related Technical Resources & Posts

Reviews

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