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Coxsackievirus IgA ELISA Kit ESR134A

$334.00

Summary

  • Virion/Serion Diagnostic Kit for research use (RUO)
  • Coxsackievirus IgA ELISA Kit
  • Suitable for IgA detection
  • Ready-to-use
  • 96 tests
Weight1 lbs
Dimensions9 × 5 × 2 in
target

Coxsackievirus reactive IgA

species reactivity

Coxsackievirus

applications

ELISA

assay type

Indirect & quantitative

available sizes

96 tests

Available product – Coxsackievirus IgA ELISA Kit ESR134A

kit
Assay type
Indirect ELISA
Research area
Infectious Disease
Sample type
Serum, plasma, whole blood
Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.
Components
Break apart microtiter test strips each with antigen coated single wells8 x 12 (96 Total)
Standard serum (ready-to-use)2 x 2 mL
Negative control serum (ready-to-use)2 mL
Anti-human-IgA-conjugate (ready-to-use)13 mL
Washing solution concentrate (sufficient for 1000ml)33.3 mL
Dilution buffer2 x 50 mL
Stopping solution15 mL
Substrate (ready-to-use)13 mL
Quality control certificate with standard curve and evaluation table1
Storage
Store at 2-8°C.
Associated products
Coxsackievirus Antigen (BA134VS01)
Cocksackie IgA Virus Control Serum (BC134A)
Cocksackie IgG Virus Control Serum (BC134G)
Cocksackie IgM Virus Control Serum (BC134M)
Cocksackievirus IgA ELISA Kit (ESR134A)
Cocksackievirus IgG ELISA Kit (ESR134G)
Cocksackievirus IgM ELISA Kit (ESR134M)
target relevance
Organism
Coxsackievirus
Structure and strains
Coxsackieviruses are a few related enteroviruses that belong to the Picornaviridae family of nonenveloped, linear, positive-sense single-stranded RNA viruses, as well as its genus Enterovirus, which also includes poliovirus and echovirus. Enteroviruses are among the most common and important human pathogens, and ordinarily its members are transmitted by the fecal oral route. Coxsackieviruses share many characteristics with poliovirus. With control of poliovirus infections in much of the world, more attention has been focused on understanding the nonpolio enteroviruses such as coxsackievirus.

Coxsackieviruses are among the leading causes of aseptic meningitis (the other usual suspects being echovirus and mumps virus).

The entry of coxsackievirus into cells, especially endothelial cells, is mediated by coxsackievirus and adenovirus receptor.
Disease
Coxsackieviruses are named after the town in Green County, New York state, where they were first identified in 1948. Coxsackieviruses of particular note are the human pathogenic species A1 to A22 and A24 as well as B1 to B6. The surface of the icosahedral virus capsid consists of the structural proteins VP1, VP2 and VP3, which are responsible for the antigenic properties and the division into the various serotypes.

Transmission of Coxsackieviruses between hosts occurs primarily by direct contact or droplet infection. In addition, the virus may be transmitted via the placenta. A further important source of infection is contaminated drinking water. The incubation period is generally 3 to 5 days. Some 90 to 95% of all Coxsackievirus infections are asymptomatic or manifest with unspecific febrile symptoms and are frequently not identified. Disease symptoms which may be caused by Coxsackieviruses include - depending upon serotype - in particular, flu-like symptoms, acute diarrhoea (summer diarrhoea) or upper respiratory tract infection (summer flu, pleurodynia, Bornholm disease), meningitis, encephalitis, pancreatitis, pericarditis, myocarditis or hepatitis. Especially, children under 10 years of age may suffer from hand, foot and mouth disease as a result of Coxsackievirus infection. This disease is characterised by aphthae in the mouth and an itchy blisterlike rash on the hands and feet.
Detection and diagnosis
The demonstration of infection by the detection of specific antibodies generally requires the analysis of serum pairs. A positive result for IgM or IgA combined with rising IgG activity serves as clear evidence of an acute or recent infection. Persisting IgM and IgA antibody levels are frequently observed in chronic infections.

Data

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
ESR134A protocol

Documents

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