| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | rabbit |
| isotype | IgG |
| clonality | polyclonal |
| concentration | 1 mg/mL |
| applications | ELISA, WB |
| available sizes | 100 µg |
rabbit anti-CCL5 polyclonal antibody 5602
$350.00
Antibody summary
- Rabbit polyclonal to CCL5
- Suitable for: ELISA, WB
- Reacts with: human
- Isotype: IgG
- 100 µg
rabbit anti-CCL5 polyclonal antibody 5602
| target relevance |
|---|
| Protein names C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)] |
| Gene names CCL5,CCL5 D17S136E SCYA5 |
| Protein family Intercrine beta (chemokine CC) family |
| Mass 9990Da |
| Function FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) (PubMed:1380064, PubMed:15923218, PubMed:16791620, PubMed:8525373, PubMed:9516414). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). {ECO:0000269|PubMed:1380064, ECO:0000269|PubMed:15923218, ECO:0000269|PubMed:16791620, ECO:0000269|PubMed:17001303, ECO:0000269|PubMed:23979485, ECO:0000269|PubMed:8525373, ECO:0000269|PubMed:9516414}. |
| Subellular location SUBCELLULAR LOCATION: Secreted. |
| Tissues TISSUE SPECIFICITY: Expressed in the follicular fluid (at protein level). T-cell and macrophage specific. {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2456327}. |
| Structure SUBUNIT: Homo and heterooligomers with other chemokines. Interacts with the brown dog tick evasin-4. {ECO:0000269|PubMed:32817341}. |
| Post-translational modification PTM: N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. {ECO:0000269|PubMed:9516414}.; PTM: N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. {ECO:0000269|PubMed:16963625}.; PTM: The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity. {ECO:0000269|PubMed:1380064}. |
| Target Relevance information above includes information from UniProt accession: P13501 |
| The UniProt Consortium |
Data
|
| Western blot All lanes: CCL5 antibody at 2µg/ml + PMBC whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 10 kDa Observed band size: 10 kDa |
Publications
| pmid | title | authors | citation |
|---|---|---|---|
| We haven't added any publications to our database yet. | |||
Protocols
| relevant to this product |
|---|
| Western blot IHC |
Documents
| # | SDS | Certificate | |
|---|---|---|---|
| Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information. | |||
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