Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded colon carcinoma stained with anti-TROP2 antibody using peroxidase-conjugate and DAB chromogen. Note the cell surface staining of tumor cells

rabbit anti-TROP2 monoclonal antibody (ZR388) 6393

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to TROP2
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Colon or breast carcinoma
Visualization: Cell surface
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6393parent Category: antibody Tags: anatomy, General & Epithelial Markers, TROP2

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-TROP2 monoclonal antibody ZR388 6393

antibody
Database link: human P09758
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Applicaiton Notes Positive control: Colon or breast carcinoma
Immunogen Recombinant fragment of human TACSTD2 protein (around aa 31-274)
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)
Protein family EPCAM family
Mass 35709Da
Function May function as a growth factor receptor.
Subellular location Membrane; Single-pass type I membrane protein.
Tissues Placenta, pancreatic carcinoma cell lines.
Post-translational modification The N-terminus is blocked.
Involvement in disease DISEASE: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. {ECO:0000269\|PubMed:10192395}. Note=The disease is caused by variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: P09758
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded colon carcinoma stained with anti-TROP2 antibody using peroxidase-conjugate and DAB chromogen. Note the cell surface staining of tumor cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.