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rabbit anti-TCCR (NT) polyclonal antibody 1242

$445.00

Antibody summary

  • Rabbit polyclonal to TCCR (NT)
  • Suitable for: ELISA,WB,IHC-P,IF
  • Isotype: Whole IgG
  • 100 µg
SKU: 1242parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

rabbit

isotype

IgG

clonality

polyclonal

concentration

1 mg/mL

applications

ICC/IF, WB

reactivity

T-Cell Cytokine Receptor (TCCR) (NT)

available sizes

100 µg

Available product – rabbit anti-TCCR (NT) polyclonal antibody 1242

antibody
Tested applications
WB,IHC,IHC,ICC/IF,ELISA
Recommended dilutions
Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 70 kD is detected.

Positive control: Human spleen tissue lysate.
Immunogen
Peptide corresponding to aa 44-59 of human TCCR precursor.
Size and concentration
100µg and lot specific
Form
liquid
Storage Instructions
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Storage buffer
PBS, pH 7.4.
Purity
immunogen affinty purifcation
Clonality
polyclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
Protein names
Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
Gene names
IL27RA,IL27RA CRL1 TCCR WSX1 UNQ296/PRO336
Protein family
Type I cytokine receptor family, Type 2 subfamily
Mass
69474Da
Function
FUNCTION: Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761). Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690, ECO:0000269|PubMed:19386761}.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Tissues
TISSUE SPECIFICITY: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. {ECO:0000269|PubMed:11057672, ECO:0000269|PubMed:9600072}.
Structure
SUBUNIT: Component of a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR which interacts with the neuroprotective peptide humanin. {ECO:0000269|PubMed:19386761}.
Domain
TOPO_DOM 3
Target Relevance information above includes information from UniProt accession : Q6UWB1
The UniProt Consortium

Data

benchmark-antibodies_anti-t-cell_cytokine_receptor_tccr_nt_antibody_124
Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 µg/mL.
benchmark-antibodies_anti-t-cell_cytokine_receptor_tccr_nt_antibody_124
Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 10 µg/mL.
benchmark-antibodies_anti-t-cell_cytokine_receptor_tccr_nt_antibody_124
Immunofluorescence of TCCR in A549 cells with TCCR antibody at 20 µg/mL.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
Western blot
IHC
ICC

Documents

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