Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | rabbit |
isotype | IgG |
clonality | polyclonal |
concentration | 1 mg/mL |
applications | ICC/IF, WB |
reactivity | STAT5A (phospho-Ser780) |
available sizes | 100 µL |
rabbit anti-STAT5A (phospho-Ser780) polyclonal antibody 1924
$366.00
Antibody summary
- Rabbit polyclonal to STAT5A (phospho-Ser780)
- Suitable for: WB,IHC
- Isotype: Whole IgG
- 100 µl
rabbit anti-STAT5A (phospho-Ser780) polyclonal antibody 1924
antibody |
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Tested applications WB,IHC,IHC |
Recommended dilutions Immunoblotting: use at dilution of 1:500-1:1,000. A band of~90kDa is detected. Immunohistochemistry: use at dilution of 1:50- 1:100. These are recommended working dilutions. End user should determine optimal dilutions for their applications. |
Immunogen Peptide sequence that includes phosphorylation site of Serine 780 (R-L-S(p)-P-P) derived from human STAT5A and conjugated to KLH. |
Size and concentration 100µL and 1 mg/mL |
Form liquid |
Storage Instructions This antibody is stable for at least one (1) year at -20°C. |
Storage buffer PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, |
Purity affinity purified |
Clonality polyclonal |
Isotype IgG |
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720 |
Isotype control Rabbit polyclonal - Isotype Control |
target relevance |
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Protein names Signal transducer and activator of transcription 5A |
Gene names STAT5A,STAT5A STAT5 |
Protein family Transcription factor STAT family |
Mass 90647Da |
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. |
Subellular location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. |
Structure Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7 (PubMed:12954634). Interacts with ERBB4 (PubMed:15534001). Interacts with EBF4 (PubMed:35939714). |
Post-translational modification Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425).; ISGylated. |
Target Relevance information above includes information from UniProt accession: P42229 |
The UniProt Consortium |
No results found |
Publications
pmid | title | authors | citation |
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We haven't added any publications to our database yet. |
relevant to this product |
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Western blot IHC |
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