Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human colon adenocarcinoma (Lynch Syndrome) stained with anti-PMS-2 antibody. Note tumor cells are negative whereas normal glands (top) are nuclear positive.

rabbit anti-PMS-2 monoclonal antibody (ZR317) 6433

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to PMS-2
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Colon
Visualization: Nuclear
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6433parent Category: antibody Tags: anatomy, GI Pathology, monoclonal, PMS-2

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-PMS-2 monoclonal antibody ZR317 6433

antibody
Database link: human P54277
Tested applications IHC
Recommended dilutions Concentrated 1:50-100
Applicaiton Notes Colon
Immunogen Recombinant full-length human ALPP protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names PMS1 protein homolog 1 (DNA mismatch repair protein PMS1)
Protein family DNA mismatch repair MutL/HexB family
Mass 105830Da
Function Probably involved in the repair of mismatches in DNA.
Subellular location Nucleus .
Structure Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262). The MutL-beta complex is a heterodimer of PMS1 and MLH1 (PubMed:10748105). Interacts with MCM9 (PubMed:26300262).
Target Relevance information above includes information from UniProt accession: P54277
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human colon adenocarcinoma (Lynch Syndrome) stained with anti-PMS-2 antibody. Note tumor cells are negative whereas normal glands (top) are nuclear positive.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.