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rabbit anti-PID/MTA2 polyclonal antibody 6449

$445.00

Antibody summary

  • Rabbit polyclonal to PID/MTA2
  • Suitable for: ELISA,WB,ICC,IF,IHC-P
  • Isotype: Whole IgG
  • 100 µg
SKU: 6449parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

rabbit

isotype

IgG

clonality

polyclonal

concentration

1 mg/mL

applications

ICC/IF, WB

reactivity

PID/MTA2

available sizes

100 µg

Available product – rabbit anti-PID/MTA2 polyclonal antibody 6449

antibody
Tested applications
WB,IHC,IHC,ICC/IF,ELISA
Recommended dilutions
Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 75 kD is detected.

Positive control: HeLa cell lysate.
Immunogen
Peptide corresponding to aa 652-668 of human PID/MTA2. This sequence differs from that of mouse by one amino acid.
Size and concentration
100µg and lot specific
Form
liquid
Storage Instructions
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Storage buffer
PBS, pH 7.4.
Purity
peptide affinty purifcation
Clonality
polyclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
Protein names
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene names
MTA2,MTA2 MTA1L1 PID
Mass
75023Da
Function
FUNCTION: May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Subellular location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
Tissues
TISSUE SPECIFICITY: Widely expressed.
Structure
SUBUNIT: Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:33283408, PubMed:28977666, PubMed:16428440). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:33283408, PubMed:16428440, PubMed:28977666). Interacts with CHD3 (PubMed:28977666). Interacts with CHD4 (PubMed:28977666). Interacts with GATAD2A (PubMed:33283408). Interacts with HDAC7 (By similarity). Interacts with MBD3 (By similarity). Interacts with p53/TP53 (PubMed:11099047). Interacts with MINT (PubMed:11331609). Interacts with PIMREG (PubMed:18757745). Interacts with NACC2 (PubMed:22926524). Interacts with ERCC6 (PubMed:26030138). Interacts with PWWP2B (By similarity). {ECO:0000250|UniProtKB:Q9R190, ECO:0000269|PubMed:11099047, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18757745, ECO:0000269|PubMed:22926524, ECO:0000269|PubMed:26030138, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
Target Relevance information above includes information from UniProt accession : O94776
The UniProt Consortium

Data

benchmark-antibodies_anti-pid-mta2_antibody_6449_1.jpg
Western blot analysis of PID expression in HeLa whole cell lysates in the absence (A) or presence (B) of blocking peptide with PID antibody at 1 µg/mL.
benchmark-antibodies_anti-pid-mta2_antibody_6449_2.jpg
Immunocytochemistry staining of HeLa using PID antibody at 10 µg/mL.
benchmark-antibodies_anti-pid-mta2_antibody_6449_3.jpg
Immunofluorescence of PID in HeLa cells with PID antibody at 10 µg/mL.
benchmark-antibodies_anti-pid-mta2_antibody_6449_4.gif
Immunohistochemistry of PID in human small intestine tissue with PID antibody at 2.5 µg/mL.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
Western blot
IHC
ICC

Documents

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