Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human Langerhans cell histiocytosis stained with anti-langerin antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells

rabbit anti-Langerin monoclonal antibody (ZR170) 6240

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to Langerin
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: skin/Langerhans cell histiocytosis
Visualization: cell surface/cytoplasm.
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6240parent Category: antibody Tags: anatomy, Dermatopathology, Langerin

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-Langerin monoclonal antibody ZR170 6240

antibody
Database link: human Q9UJ71
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Applicaiton Notes Positive control: skin/Langerhans cell histiocytosis
Immunogen Recombinant fragment (around aa50-250) of human Langerin protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names C-type lectin domain family 4 member K (Langerin) (CD antigen CD207)
Mass 36725Da
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Subellular location Membrane ; Single-pass type II membrane protein . Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Tissues Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Structure Homotrimer.
Domain DOMAIN 202..320; /note="C-type lectin"; /evidence="ECO:0000255\|PROSITE-ProRule:PRU00040"
Involvement in disease Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity. Note=The disease is caused by variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: Q9UJ71
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human Langerhans cell histiocytosis stained with anti-langerin antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.