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rabbit anti-IRAK2 polyclonal antibody 8028

$445.00

Antibody summary

  • Rabbit polyclonal to IRAK2
  • Suitable for: ELISA,WB,ICC,IF
  • Isotype: IgG
  • 100 µg
SKU: 8028parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

rabbit

isotype

IgG

clonality

polyclonal

concentration

1 mg/mL

applications

ICC/IF, WB

reactivity

IRAK2

available sizes

100 µg

Available product – rabbit anti-IRAK2 polyclonal antibody 8028

antibody
Tested applications
WB,ICC/IF,ELISA
Recommended dilutions
Immunoblotting: use at 1:500-1:1,000 dilution.

Positive control: Whole cell lysate from HeLa cells or K562 cells. No cross- reactivity with IRAK.
Immunogen
Peptide corresponding to aa 546- 564 of human IRAK2.
Size and concentration
100µg and lot specific
Form
liquid
Storage Instructions
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Storage buffer
PBS, pH 7.4.
Purity
peptide affinty purifcation
Clonality
polyclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
Protein names
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
Gene names
IRAK2,IRAK2
Protein family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
Mass
69433Da
Function
FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.
Tissues
TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:9374458}.
Structure
SUBUNIT: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. {ECO:0000269|PubMed:9374458}.
Target Relevance information above includes information from UniProt accession : O43187
The UniProt Consortium

Data

benchmark-antibodies_anti-irak2_antibody_8028_1.jpg
Western blot analysis of IRAK2 in HeLa (H) and K562 (K) whole cell lysate with IRAK2 antibody (C2) at 2 µg/mL.
benchmark-antibodies_anti-irak2_antibody_8028_2.jpg
Immunocytochemical staining of HeLa cells using IRAK2 antibody at 2 µg/mL.
benchmark-antibodies_anti-irak2_antibody_8028_3.jpg
Immunofluorescence of IRAK-2 in Hela cells with IRAK-2 antibody at 10 µg/mL.
benchmark-antibodies_anti-irak2_antibody_8028_4.gif
Immunofluorescence of IRAK-M in human spleen tissue with IRAK M antibody at 20 µg/mL. Green: IRAK-2 Antibody (8028)
Blue: DAPI staining

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
Western blot
IHC
ICC

Documents

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