| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | rabbit |
| isotype | IgG |
| clonality | polyclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Interleukin-21 Receptor (IL-21R) (NT) |
| available sizes | 100 µg |
rabbit anti-IL-21R (NT) polyclonal antibody 9752
$445.00
Antibody summary
- Rabbit polyclonal to IL-21R (NT)
- Suitable for: ELISA,WB,IF
- Isotype: Whole IgG
- 100 µg
rabbit anti-IL-21R (NT) polyclonal antibody 9752
| antibody |
|---|
| Tested applications WB,ICC/IF,ELISA |
| Recommended dilutions Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 60 kD is detected. Positive control: Raji cell lysate. |
| Immunogen Peptide corresponding to aa 20-32 of human IL-21R precursor. |
| Size and concentration 100µg and lot specific |
| Form liquid |
| Storage Instructions This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. |
| Storage buffer PBS, pH 7.4. |
| Purity peptide affinity purification |
| Clonality polyclonal |
| Isotype IgG |
| Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720 |
| Isotype control Rabbit polyclonal - Isotype Control |
| target relevance |
|---|
| Protein names Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360) |
| Gene names IL21R,IL21R NILR UNQ3121/PRO10273 |
| Protein family Type I cytokine receptor family, Type 4 subfamily |
| Mass 59130Da |
| Function FUNCTION: This is a receptor for interleukin-21. |
| Subellular location SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Tissues TISSUE SPECIFICITY: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen. |
| Structure SUBUNIT: Heterodimer with the common gamma subunit. Associates with JAK1. {ECO:0000269|PubMed:22235133}. |
| Post-translational modification PTM: C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. |
| Domain DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. {ECO:0000269|PubMed:22235133}.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation. {ECO:0000269|PubMed:22235133}. |
| Involvement in disease DISEASE: Immunodeficiency 56 (IMD56) [MIM:615207]: An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. {ECO:0000269|PubMed:23440042}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6. |
| Target Relevance information above includes information from UniProt accession: Q9HBE5 |
| The UniProt Consortium |
Data
 |
| Western blot analysis of IL-21 receptor expression in human Raji cell lysate with IL-21 receptor antibody at 1 µg/mL. |
 |
| Immunofluorescence of IL-21 Receptor in A431 cells with IL-21 Receptor antibody at 20 µg/mL.
Green: IL-21 Receptor Antibody (9752) Blue: DAPI staining |
Publications
| pmid | title | authors | citation |
|---|---|---|---|
| We haven't added any publications to our database yet. | |||
Protocols
| relevant to this product |
|---|
| Western blot IHC ICC |
Documents
| # | SDS | Certificate | |
|---|---|---|---|
| Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information. | |||
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